The Binkhorst Medal Lecture Biologic relationship between poly(methyl methacrylate) intraocular lenses and uveal tissue

Stephen A. Obstbaum

doi:10.1016/S0886-3350(13)80897-8

The Binkhorst Medal Lecture Biologic relationship between poly(methyl methacrylate) intraocular lenses and uveal tissue

Stephen A. Obstbaum

Icahn School of Medicine at Mount Sinai

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

Implantation of a poly(methyl methacrylate) (PMMA) intraocular lens (IOL) after cataract surgery is associated with breakdown of the blood-ocular barrier and a foreign body inflammatory response. Although the material is biocompatible, it is not inert. The history of PMMA IOL implantation has reflected mechanical, chemical, and immunological interactions between the IOL and ocular tissues. The common link in these events is instability of the blood-ocular barrier. In this lecture, I discuss the nature of these interactions and present evidence that currently investigated methods of surface modification and capsular bag IOL implantation are effective in stabilizing the blood-ocular barrier.

Original language	English
Pages (from-to)	219-231
Number of pages	13
Journal	Journal of Cataract and Refractive Surgery
Volume	18
Issue number	3
DOIs	https://doi.org/10.1016/S0886-3350(13)80897-8
State	Published - 1992

Keywords

biocompatibility
blood-ocular barrier
capsular bag implantation
foreign body inflammatory reaction
iris chafing
pigmentary dispersion
surface modification
tissue-implant interface

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10.1016/S0886-3350(13)80897-8

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abstract = "Implantation of a poly(methyl methacrylate) (PMMA) intraocular lens (IOL) after cataract surgery is associated with breakdown of the blood-ocular barrier and a foreign body inflammatory response. Although the material is biocompatible, it is not inert. The history of PMMA IOL implantation has reflected mechanical, chemical, and immunological interactions between the IOL and ocular tissues. The common link in these events is instability of the blood-ocular barrier. In this lecture, I discuss the nature of these interactions and present evidence that currently investigated methods of surface modification and capsular bag IOL implantation are effective in stabilizing the blood-ocular barrier.",

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AB - Implantation of a poly(methyl methacrylate) (PMMA) intraocular lens (IOL) after cataract surgery is associated with breakdown of the blood-ocular barrier and a foreign body inflammatory response. Although the material is biocompatible, it is not inert. The history of PMMA IOL implantation has reflected mechanical, chemical, and immunological interactions between the IOL and ocular tissues. The common link in these events is instability of the blood-ocular barrier. In this lecture, I discuss the nature of these interactions and present evidence that currently investigated methods of surface modification and capsular bag IOL implantation are effective in stabilizing the blood-ocular barrier.

KW - biocompatibility

KW - blood-ocular barrier

KW - capsular bag implantation

KW - foreign body inflammatory reaction

KW - iris chafing

KW - pigmentary dispersion

KW - surface modification

KW - tissue-implant interface

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JF - Journal of Cataract and Refractive Surgery

IS - 3

ER -

The Binkhorst Medal Lecture Biologic relationship between poly(methyl methacrylate) intraocular lenses and uveal tissue

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Keywords

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