The BCL-2 Family Reunion

Jerry E. Chipuk, Tudor Moldoveanu, Fabien Llambi, Melissa J. Parsons, Douglas R. Green

Research output: Contribution to journalReview articlepeer-review

1244 Scopus citations


B cell CLL/lymphoma-2 (BCL-2) and its relatives comprise the BCL-2 family of proteins, which were originally characterized with respect to their roles in controlling outer mitochondrial membrane integrity and apoptosis. Current observations expand BCL-2 family function to include numerous cellular pathways. Here we will discuss the mechanisms and functions of the BCL-2 family in the context of these pathways, highlighting the complex integration and regulation of the BCL-2 family in cell fate decisions.

Original languageEnglish
Pages (from-to)299-310
Number of pages12
JournalMolecular Cell
Issue number3
StatePublished - 12 Feb 2010
Externally publishedYes


Dive into the research topics of 'The BCL-2 Family Reunion'. Together they form a unique fingerprint.

Cite this