Original language | English |
---|---|
Pages (from-to) | 511-512 |
Number of pages | 2 |
Journal | Diseases of the Colon and Rectum |
Volume | 35 |
Issue number | 5 |
State | Published - May 1992 |
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In: Diseases of the Colon and Rectum, Vol. 35, No. 5, 05.1992, p. 511-512.
Research output: Contribution to journal › Letter › peer-review
TY - JOUR
T1 - The authors reply
AU - Guillemot, François
AU - Neut, Christelle
AU - Colombel, Jean Frédéric
AU - Cortot, Antoine
N1 - Funding Information: hile using a double label. indirect immunoflu-orescence technique to examine the class II histocompatibility antigen-expressing capac-ity of human dermal microvascular endothe-lial cells (DMVEC) in situ, we were surprised to find a previously unrecognized population of perivascular dendritic cells that appeared to display greater amounts of HLA-DR antigen than the endothelial cells with which they were intimately associated [1]. Others have commented upon a class II antigen positive. dendritic-appearing cell in normal adult [2] and fetal [3] human dermis; however, such cells have previously been felt to be rather randomly distributed throughout this tissue. In addition, a ce ll having a veiled morphology has also been noted to surround nonlesional human dermal microvessels [4]. While data regarding this latter cell type's ability to express HLA-D region antigens have not yet been formally presented, very recent observations have suggested that it might be capable of doing so (personal communica- Manuscript received May 18. 1988; accepted for publication January 25, 1989. This work was supported by NIH grants AR09989. AM 19101 and HD/ 14358 as well as a grant from the Lester I. Conrad Research Foundation. Dr. Sontheimer is the recipient of NIH Research Career Development Award, AR01784. Reprint requests to: R.D. Sontheimer. MD, Department of Dermatology • U.T. Southwestern Medical Center. 5323 Harry Hines Blvd., Dallas TX 75235-9069. Abbreviations: DMVEC: dermal microvascular endothelial cell (s) DPDC: dermal perivascular dendritic cell (5) DPDM: dermal perivascular dendritic macrophage (5) FITC: fluorescein isothiocyanate PBS: phosphate buffered saline TRITC: tetramethyl rhodamine isothiocyanate tions, Dr. I.M. Braverman). If this perivascular veil cell is confirmed to constitutively express class II histocompatibility antigens, it would be closely related to the cell that we have observed in the current study. Both the dermal histiocyte and veil cell have been felt by some to be related to the fibroblast lineage [2,4]. Because the dermal perivascular dendritic cell (DPDC) which we have observed in the present study appears to have a macrophage rather than fibroblast phenotype. it was our impression that this cell has not yet been formally studied. Therefore, we initiated a systematic examination of the phenotypic and ultrastructural characteristics of this previously uncharacterized cell type.
PY - 1992/5
Y1 - 1992/5
UR - http://www.scopus.com/inward/record.url?scp=84933471460&partnerID=8YFLogxK
M3 - Letter
AN - SCOPUS:84933471460
SN - 0012-3706
VL - 35
SP - 511
EP - 512
JO - Diseases of the Colon and Rectum
JF - Diseases of the Colon and Rectum
IS - 5
ER -