@article{ec0a8771a6ad4f5e843acf949a39cad2,
title = "The atypical cadherin flamingo links frizzled and notch signaling in planar polarity establishment in the Drosophila eye",
abstract = "Planar cell polarity is established in the Drosophila eye through distinct fate specification of photoreceptors R3 and R4 by a two-tiered mechanism employing Fz and Notch signaling: Fz signaling specifies R3 and induces DI to activate Notch in R4. We show that the atypical cadherin Flamingo (Fmi) plays critical, but distinct, roles in both R3 and R4. Fmi is first enriched at equatorial cell borders of R3/R4, positively interacting with Fz/Dsh. Subsequently, Fmi is upregulated in R4 by Notch and functions to downregulate DI expression by antagonizing Fz signaling. This in turn amplifies and enforces the initial Fz-signaling bias in the R3/R4 pair. Our results reveal differences in the planar cell polarity genetic circuitry between the eye and the wing.",
author = "Gishnu Das and Jessica Reynolds-Kenneally and Marek Mlodzik",
note = "Funding Information: We are most grateful to T. Uemura and T. Usui for generous gifts of all Fmi reagents and to T. Wolff for sharing unpublished data. We thank P. Adler, R. Barrio, K. Basler, S. Bray, B. Dickson, S. Eaton, R. Fehon, M. Haenlin, E. Knust, T. Laverty, G. Rubin, K. Saigo, D. Strutt, A. Tomlinson, J. Treisman, T. Wolff, L. Zipursky, the Developmental Studies Hybridoma Bank, and the Bloomington Stock Center for fly strains and antibodies. Confocal laser microscopy was performed at the MSSM-Microscopy SRF, supported by an NIH shared instrumentation grant (1S10 RR0 9145-01) and an NSF Major Research Instrumentation grant (DBI-9724504). We thank all members of the Mlodzik lab for helpful discussions, patience, technical advice, and comments on the manuscript. This research was supported by NIH grant EY13256.",
year = "2002",
doi = "10.1016/S1534-5807(02)00147-8",
language = "English",
volume = "2",
pages = "655--666",
journal = "Developmental Cell",
issn = "1534-5807",
publisher = "Cell Press",
number = "5",
}