Development of the asymmetric [C+NC+CC] coupling reaction is described. This reaction assembles aldehyde(C), amine (NC), and alkene (CC) components in a predictable and controlled fashion to give highly functionalized pyrrolidines. The utility of the asymmetric [C+NC+CC] coupling reaction is demonstrated by its application to an efficientformal total synthesis of cyanocycline A.
- Asymmetric synthesis
- Azomethine ylide cycloaddition
- Cyanocycline A
- Multicomponent reaction
- Pyrrolidine synthesis