Abstract
Development of the asymmetric [C+NC+CC] coupling reaction is described. This reaction assembles aldehyde(C), amine (NC), and alkene (CC) components in a predictable and controlled fashion to give highly functionalized pyrrolidines. The utility of the asymmetric [C+NC+CC] coupling reaction is demonstrated by its application to an efficientformal total synthesis of cyanocycline A.
| Original language | English |
|---|---|
| Pages (from-to) | 348-362 |
| Number of pages | 15 |
| Journal | Current Organic Synthesis |
| Volume | 7 |
| Issue number | 4 |
| DOIs | |
| State | Published - 2010 |
| Externally published | Yes |
Keywords
- Asymmetric synthesis
- Azomethine ylide cycloaddition
- Cyanocycline A
- Multicomponent reaction
- Pyrrolidine synthesis