@article{7c1df3d33f124552b73209c068ede975,
title = "The associations of anthropometric, behavioural and sociodemographic factors with circulating concentrations of IGF-I, IGF-II, IGFBP-1, IGFBP-2 and IGFBP-3 in a pooled analysis of 16,024 men from 22 studies",
abstract = "Insulin-like growth factors (IGFs) and insulin-like growth factor binding proteins (IGFBPs) have been implicated in the aetiology of several cancers. To better understand whether anthropometric, behavioural and sociodemographic factors may play a role in cancer risk via IGF signalling, we examined the cross-sectional associations of these exposures with circulating concentrations of IGFs (IGF-I and IGF-II) and IGFBPs (IGFBP-1, IGFBP-2 and IGFBP-3). The Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group dataset includes individual participant data from 16,024 male controls (i.e. without prostate cancer) aged 22–89 years from 22 prospective studies. Geometric means of protein concentrations were estimated using analysis of variance, adjusted for relevant covariates. Older age was associated with higher concentrations of IGFBP-1 and IGFBP-2 and lower concentrations of IGF-I, IGF-II and IGFBP-3. Higher body mass index was associated with lower concentrations of IGFBP-1 and IGFBP-2. Taller height was associated with higher concentrations of IGF-I and IGFBP-3 and lower concentrations of IGFBP-1. Smokers had higher concentrations of IGFBP-1 and IGFBP-2 and lower concentrations of IGFBP-3 than nonsmokers. Higher alcohol consumption was associated with higher concentrations of IGF-II and lower concentrations of IGF-I and IGFBP-2. African Americans had lower concentrations of IGF-II, IGFBP-1, IGFBP-2 and IGFBP-3 and Hispanics had lower IGF-I, IGF-II and IGFBP-3 than non-Hispanic whites. These findings indicate that a range of anthropometric, behavioural and sociodemographic factors are associated with circulating concentrations of IGFs and IGFBPs in men, which will lead to a greater understanding of the mechanisms through which these factors influence cancer risk.",
keywords = "IGFBPs, IGFs, correlates, pooled analysis",
author = "Watts, {Eleanor L.} and Aurora Perez-Cornago and Appleby, {Paul N.} and Demetrius Albanes and Eva Ardanaz and Amanda Black and Bueno-de-Mesquita, {H. Bas} and Chan, {June M.} and Chu Chen and Chubb, {S. A.Paul} and Cook, {Michael B.} and M{\'e}lanie Deschasaux and Donovan, {Jenny L.} and English, {Dallas R.} and Leon Flicker and Freedman, {Neal D.} and Pilar Galan and Giles, {Graham G.} and Giovannucci, {Edward L.} and Gunter, {Marc J.} and Habel, {Laurel A.} and Christel H{\"a}ggstr{\"o}m and Christopher Haiman and Hamdy, {Freddie C.} and Serge Hercberg and Holly, {Jeff M.} and Jiaqi Huang and Huang, {Wen Yi} and Mattias Johansson and Rudolf Kaaks and Tatsuhiko Kubo and Lane, {J. Athene} and Layne, {Tracy M.} and {Le Marchand}, Loic and Martin, {Richard M.} and Metter, {E. Jeffrey} and Kazuya Mikami and Milne, {Roger L.} and Morris, {Howard A.} and Mucci, {Lorelei A.} and Neal, {David E.} and Neuhouser, {Marian L.} and Oliver, {Steven E.} and Kim Overvad and Kotaro Ozasa and Valeria Pala and Pernar, {Claire H.} and Michael Pollak and Rowlands, {Mari Anne} and Schaefer, {Catherine A.} and Schenk, {Jeannette M.} and P{\"a}r Stattin and Akiko Tamakoshi and Elin Thysell and Mathilde Touvier and Antonia Trichopoulou and Tsilidis, {Konstantinos K.} and {Van Den Eeden}, {Stephen K.} and Weinstein, {Stephanie J.} and Lynne Wilkens and Yeap, {Bu B.} and Key, {Timothy J.} and Allen, {Naomi E.} and Travis, {Ruth C.}",
note = "Funding Information: Centralised pooling, checking and data analysis was supported by Cancer Research UK grants C8221/A19170 and C8221/A20986. The authors thank the men who participated in the collaborating studies, the research staff, collaborating laboratories, and funding agencies in each of the studies. We would also like to thank Dr Barbara Cohn, Piera M. Cirillo and Dr Alice S. Whittemore for their work and contribution from the Child Health and Development Studies, Public Health Institute, Berkeley California, USA. We would also like to thank Dr Nicholas Wald and Dr Joan Morris for their work and contribution from the British United Provident Association Study. Richard Martin was supported by a Cancer Research UK Programme Grant, the Integrative Cancer Epidemiology Programme (C18281/A19169), and by the NIHR Bristol Biomedical Research Centre, a partnership between the University Hospitals Bristol NHS Foundation Trust and the University of Bristol. The views expressed in this publication are those of the author(s) and not necessarily those of the NHS, the National Institute for Health Research or the Department of Health. The Health Professionals Follow-up Study is supported by the grant U01 CA 167552 from the National Cancer Institute. EPIC-Greece was supported by the Hellenic Health Foundation. Publisher Copyright: {\textcopyright} 2019 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC",
year = "2019",
month = dec,
day = "15",
doi = "10.1002/ijc.32276",
language = "English",
volume = "145",
pages = "3244--3256",
journal = "International Journal of Cancer",
issn = "0020-7136",
publisher = "Wiley-Liss Inc.",
number = "12",
}