TY - JOUR
T1 - The association of lead exposure during pregnancy and childhood anthropometry in the Mexican PROGRESS cohort
AU - Renzetti, Stefano
AU - Just, Allan C.
AU - Burris, Heather H.
AU - Oken, Emily
AU - Amarasiriwardena, Chitra
AU - Svensson, Katherine
AU - Mercado-García, Adriana
AU - Cantoral, Alejandra
AU - Schnaas, Lourdes
AU - Baccarelli, Andrea A.
AU - Wright, Robert O.
AU - Téllez-Rojo, Martha María
N1 - Funding Information:
This work was supported by NIH grants R01 ES014930 , R01 ES013744 , R01 ES021357 , P30 ES023515 ; Dr. Just received funding from NIH grant R00 ES023450. Dr. Oken received funding from NIH grant K24 HD069408. Dr. Burris received funding from NIH grant K23 ES022242. Co-Investigators and staff at the INSP were also supported and received partial funding from the National Institute of Public Health / Ministry of Health of Mexico . We acknowledge American British Cowdray Medical Center for providing research facilities which made it possible to conduct the study.
Publisher Copyright:
© 2016 Elsevier Inc.
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Lead exposure during pregnancy remains a public health problem with potential lifelong impacts on children's growth and development. Mexico is unique in that stunting and obesity are both major public health concerns in children. This situation might be exacerbated by lead exposure which remains more common in Mexico than in the United States due in part to the use of lead glazed pottery in food preparation and storage. Our objective is to determine how lead exposure during pregnancy is associated with children's growth parameters, including height, weight, body mass index and percentage body fat measured between ages 4–6 years old in a Mexico City pregnancy cohort. Blood lead was collected in the 2nd and 3rd trimester of pregnancy as well as at delivery. Bone lead was assessed in mothers as a long term exposure biomarker. We performed multivariable linear regression analyses to assess the association between each of these lead exposure biomarkers and child anthropometry. We found a significant negative association between maternal 3rd trimester blood lead concentration and offspring height for age (β−0.10; 95% CI −0.19, −0.01), and a negative association between maternal 3rd trimester blood lead concentration and weight for age (β−0.11; 95% CI −0.22,−0.003). Our results in this Mexican population add to previous findings of an association of lead and decreased stature and weight in early childhood. Ongoing follow-up and longitudinal analyses may help elucidate how this impacts growth trajectory and other children's health outcomes.
AB - Lead exposure during pregnancy remains a public health problem with potential lifelong impacts on children's growth and development. Mexico is unique in that stunting and obesity are both major public health concerns in children. This situation might be exacerbated by lead exposure which remains more common in Mexico than in the United States due in part to the use of lead glazed pottery in food preparation and storage. Our objective is to determine how lead exposure during pregnancy is associated with children's growth parameters, including height, weight, body mass index and percentage body fat measured between ages 4–6 years old in a Mexico City pregnancy cohort. Blood lead was collected in the 2nd and 3rd trimester of pregnancy as well as at delivery. Bone lead was assessed in mothers as a long term exposure biomarker. We performed multivariable linear regression analyses to assess the association between each of these lead exposure biomarkers and child anthropometry. We found a significant negative association between maternal 3rd trimester blood lead concentration and offspring height for age (β−0.10; 95% CI −0.19, −0.01), and a negative association between maternal 3rd trimester blood lead concentration and weight for age (β−0.11; 95% CI −0.22,−0.003). Our results in this Mexican population add to previous findings of an association of lead and decreased stature and weight in early childhood. Ongoing follow-up and longitudinal analyses may help elucidate how this impacts growth trajectory and other children's health outcomes.
KW - Anthropometry
KW - Child
KW - Lead
KW - Pregnancy
KW - Stunting
UR - http://www.scopus.com/inward/record.url?scp=84993961068&partnerID=8YFLogxK
U2 - 10.1016/j.envres.2016.10.014
DO - 10.1016/j.envres.2016.10.014
M3 - Article
C2 - 27810680
AN - SCOPUS:84993961068
SN - 0013-9351
VL - 152
SP - 226
EP - 232
JO - Environmental Research
JF - Environmental Research
ER -