TY - JOUR
T1 - The association of expired nitric oxide with occupational particulate metal exposure
AU - Kim, Jee Young
AU - Hauser, Russ
AU - Wand, Matthew P.
AU - Herrick, Robert F.
AU - Amarasiriwardena, Chitra J.
AU - Christiani, David C.
N1 - Funding Information:
This study was supported by NIH Grants ES09860 and ES00002, NIOSH Grant OH00152, and the Mickey Leland National Urban Air Toxics Research Center. Ms. Kim was supported by the Harvard–NIOSH Education and Research Center Training Grant T42110421.
PY - 2003/10
Y1 - 2003/10
N2 - Toxicologic studies have shown that soluble transition metals in residual oil fly ash (ROFA) can induce pulmonary injury. In this study, we investigated the association between the fractional concentration of expired nitric oxide (FENO) and exposure to metal constituents of particulate matter with an aerodynamic mass median diameter≤2.5μm (PM2.5) in boilermakers exposed to ROFA and metal fume. Metals investigated included vanadium, chromium, manganese, nickel, copper, and lead. Subjects were monitored for 5 consecutive days during boiler repair overhauls in 1999 (n=20) and 2000 (n=14). In 1999, we found a significant inverse association between log-transformed FENO and PM2.5 metal concentrations. LogFENO changed by -0.03 (95% CI: -0.04, -0.01), -0.56 (95% CI: -0.88, -0.24), -0.09 (95% CI: -0.16, -0.02), and -0.04 (95% CI: -0.07, -0.02) per μg/m3 of PM2.5 vanadium, chromium, manganese, and nickel, respectively. In 2000, no significant associations were observed, most likely due to exposure misclassification resulting from the use of respirators. The inverse association between PM2.5 metal exposure and F ENO in subjects with limited respirator usage suggests that soluble transition metals might be partially responsible for the adverse pulmonary responses seen in workers exposed to ROFA.
AB - Toxicologic studies have shown that soluble transition metals in residual oil fly ash (ROFA) can induce pulmonary injury. In this study, we investigated the association between the fractional concentration of expired nitric oxide (FENO) and exposure to metal constituents of particulate matter with an aerodynamic mass median diameter≤2.5μm (PM2.5) in boilermakers exposed to ROFA and metal fume. Metals investigated included vanadium, chromium, manganese, nickel, copper, and lead. Subjects were monitored for 5 consecutive days during boiler repair overhauls in 1999 (n=20) and 2000 (n=14). In 1999, we found a significant inverse association between log-transformed FENO and PM2.5 metal concentrations. LogFENO changed by -0.03 (95% CI: -0.04, -0.01), -0.56 (95% CI: -0.88, -0.24), -0.09 (95% CI: -0.16, -0.02), and -0.04 (95% CI: -0.07, -0.02) per μg/m3 of PM2.5 vanadium, chromium, manganese, and nickel, respectively. In 2000, no significant associations were observed, most likely due to exposure misclassification resulting from the use of respirators. The inverse association between PM2.5 metal exposure and F ENO in subjects with limited respirator usage suggests that soluble transition metals might be partially responsible for the adverse pulmonary responses seen in workers exposed to ROFA.
KW - Air pollutants
KW - Epidemiology
KW - Metals
KW - Nitric oxide
KW - Occupational
KW - Particulate matter
UR - http://www.scopus.com/inward/record.url?scp=0042330274&partnerID=8YFLogxK
U2 - 10.1016/S0013-9351(03)00017-3
DO - 10.1016/S0013-9351(03)00017-3
M3 - Article
C2 - 12963400
AN - SCOPUS:0042330274
SN - 0013-9351
VL - 93
SP - 158
EP - 166
JO - Environmental Research
JF - Environmental Research
IS - 2
ER -