The association of elective cessation of tocolysis and preterm birth in singleton gestations

Andrei Rebarber, Jane Cleary-Goldman, Niki Istwan, Debbie Rhea, Gary Stanziano, Daniel Saltzman

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4 Scopus citations


We evaluated outcomes following tocolysis discontinuation in singleton pregnancies between 33.0 and 36.9 weeks' gestation. We performed a retrospective analysis of singleton pregnancies prescribed continuous subcutaneous terbutaline tocolysis. Patients without indicated preterm delivery discontinuing treatment between 33.0 and 36.9 weeks were evaluated (n = 4253). Data were grouped by week at treatment discontinuation. Outcomes were compared for each week. Approximately 55% (2316/4253) delivered preterm (< 37 weeks). After treatment discontinuation, 58.1% (2472/4253) of patients delivered within 7 days and 41.2% (1752/4253) within 3 days. Median number of days from discontinuation to delivery was 5 (range, 0 to 65). Incidence of low birth weight (≤ 2500 g), neonatal intensive care unit admissions, days in nursery, and estimated charges decreased with each additional week of tocolysis (all p < 0.05, adjusted for multiple comparisons). Tocolysis discontinuation prior to term is associated with late-preterm birth, adverse neonatal outcomes, and increased estimated health care costs.

Original languageEnglish
Pages (from-to)351-355
Number of pages5
JournalAmerican Journal of Perinatology
Issue number5
StatePublished - May 2009


  • Late-preterm birth
  • Neonatal outcome
  • Prematurity cost
  • Terbutaline
  • Tocolysis


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