The association between prenatal F2-isoprostanes and child wheeze/asthma and modification by maternal race

Margaret A. Adgent, Tebeb Gebretsadik, Cordelia R. Elaiho, Ginger L. Milne, Paul Moore, Terryl J. Hartman, Whitney Cowell, Cecilia S. Alcala, Nicole Bush, Robert Davis, Kaja Z. LeWinn, Frances A. Tylavsky, Rosalind J. Wright, Kecia N. Carroll

Research output: Contribution to journalArticlepeer-review


Background: Childhood wheeze, asthma, and allergic rhinitis are common and likely have prenatal origins. Oxidative stress is associated with respiratory disease, but the association of oxidative stress during the prenatal period with development of respiratory and atopic disease in childhood, particularly beyond the infancy period, is unknown. This study aims to investigate associations between prenatal oxidative stress, measured by maternal urinary F2-isoprostanes, and child respiratory outcomes, including effect modification by maternal race. Methods: We prospectively studied Black (n = 717) and White (n = 363) mother-child dyads. We measured F2-isoprostanes in 2nd-trimester urine (ng/mg-creatinine). At approximately age 4, we obtained parent report of provider-diagnosed asthma (ever), current wheeze, current asthma (diagnosis, symptoms and/or medication), and current allergic rhinitis (current defined as previous 12 months). We used multivariable logistic regression to estimate adjusted odds ratios (aOR) and 95% confidence intervals (95%CI) per interquartile range (IQR) increase in F2-isoprostane concentration, controlling for confounders. We examined modification by maternal race using interaction terms. Results: The prevalence of provider-diagnosed asthma and current wheeze, asthma and allergic rhinitis was 14%, 19%, 15%, and 24%, respectively. Median (IQR) F2-isoprostane levels were 2.1 (1.6, 2.9) ng/mg-creatinine. Associations between prenatal F2-isoprostanes and provider-diagnosed asthma, current wheeze, and current asthma were modified by maternal race. Results were strongest for current wheeze (aOR [95%CI]: 1.55 [1.16, 2.06] for White; 0.98 [0.78, 1.22] for Black; p-interaction = 0.01). We observed no association between F2-isoprostanes and allergic rhinitis. Conclusion: Prenatal urinary F2-isoprostanes may be a marker associated with childhood wheeze/asthma in certain populations. Research is needed to understand underlying mechanisms and racial differences.

Original languageEnglish
Pages (from-to)85-90
Number of pages6
JournalFree Radical Biology and Medicine
StatePublished - 20 Aug 2022


  • Allergic rhinitis
  • Asthma
  • Isoprostane
  • Oxidative stress
  • Pediatric
  • Prenatal
  • Wheezing


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