TY - JOUR
T1 - The association between duration of breastfeeding and childhood asthma outcomes
AU - Wilson, Keadrea
AU - Gebretsadik, Tebeb
AU - Adgent, Margaret A.
AU - Loftus, Christine
AU - Karr, Catherine
AU - Moore, Paul E.
AU - Sathyanarayana, Sheela
AU - Byington, Nora
AU - Barrett, Emily
AU - Bush, Nicole
AU - Nguyen, Ruby
AU - Hartman, Terry J.
AU - LeWinn, Kaja Z.
AU - Calvert, Alexis
AU - Mason, W. Alex
AU - Carroll, Kecia N.
N1 - Publisher Copyright:
© 2022 American College of Allergy, Asthma & Immunology
PY - 2022/8
Y1 - 2022/8
N2 - Background: Postnatal exposures, including breastfeeding, may influence asthma development. Objective: To investigate the association between breastfeeding duration and child asthma. Methods: We studied 2021 mother-child dyads in the ECHO PATHWAYS consortium of prospective pregnancy cohorts (GAPPS, CANDLE, TIDES). Women reported the duration of any and exclusive breastfeeding and child asthma outcomes during follow-up at child age 4 to 6 years. Outcomes included current wheeze (previous 12 months), ever asthma, current asthma (having ≥2 of current wheeze, ever asthma, medication use in past 12-24 months), and strict current asthma (ever asthma with either or both current wheeze and medication use in past 12-24 months). We used multivariable logistic regression to assess associations (odds ratios and 95% confidence intervals) between breastfeeding and asthma outcomes adjusting for potential confounders. We assessed effect modification by mode of delivery, infant sex, and maternal asthma. Results: Among women, 33%, 13%, 9%, and 45% reported 0 to less than 2, 2 to 4, 5 to 6, and more than 6 months of any breastfeeding, respectively. The duration of any breastfeeding had a protective linear trend with ever asthma but no other outcomes. There was a duration-dependent protective association of exclusive breastfeeding and child asthma outcomes (eg, current asthma adjusted odds ratio [95% confidence interval], 0.64 [0.41-1.02], 0.61 [0.38-0.98], and 0.52 (0.31-0.87) for 2to 4 months, 5 to 6 months, and more than 6 months, respectively, compared with <2 months). For exclusive breastfeeding, protective associations were stronger in dyads with children born by vaginal vs cesarean delivery although interactions did not reach statistical significance (Pinteractions 0.12-0.40). Conclusion: Longer duration of exclusive breastfeeding had a protective association with child asthma.
AB - Background: Postnatal exposures, including breastfeeding, may influence asthma development. Objective: To investigate the association between breastfeeding duration and child asthma. Methods: We studied 2021 mother-child dyads in the ECHO PATHWAYS consortium of prospective pregnancy cohorts (GAPPS, CANDLE, TIDES). Women reported the duration of any and exclusive breastfeeding and child asthma outcomes during follow-up at child age 4 to 6 years. Outcomes included current wheeze (previous 12 months), ever asthma, current asthma (having ≥2 of current wheeze, ever asthma, medication use in past 12-24 months), and strict current asthma (ever asthma with either or both current wheeze and medication use in past 12-24 months). We used multivariable logistic regression to assess associations (odds ratios and 95% confidence intervals) between breastfeeding and asthma outcomes adjusting for potential confounders. We assessed effect modification by mode of delivery, infant sex, and maternal asthma. Results: Among women, 33%, 13%, 9%, and 45% reported 0 to less than 2, 2 to 4, 5 to 6, and more than 6 months of any breastfeeding, respectively. The duration of any breastfeeding had a protective linear trend with ever asthma but no other outcomes. There was a duration-dependent protective association of exclusive breastfeeding and child asthma outcomes (eg, current asthma adjusted odds ratio [95% confidence interval], 0.64 [0.41-1.02], 0.61 [0.38-0.98], and 0.52 (0.31-0.87) for 2to 4 months, 5 to 6 months, and more than 6 months, respectively, compared with <2 months). For exclusive breastfeeding, protective associations were stronger in dyads with children born by vaginal vs cesarean delivery although interactions did not reach statistical significance (Pinteractions 0.12-0.40). Conclusion: Longer duration of exclusive breastfeeding had a protective association with child asthma.
UR - https://www.scopus.com/pages/publications/85131834081
U2 - 10.1016/j.anai.2022.04.034
DO - 10.1016/j.anai.2022.04.034
M3 - Article
C2 - 35552008
AN - SCOPUS:85131834081
SN - 1081-1206
VL - 129
SP - 205
EP - 211
JO - Annals of Allergy, Asthma and Immunology
JF - Annals of Allergy, Asthma and Immunology
IS - 2
ER -