The association between dietary fiber intake and gastric cancer: a pooled analysis of 11 case–control studies

Giulia Collatuzzo, Jacqueline Cortez Lainez, Claudio Pelucchi, Eva Negri, Rossella Bonzi, Domenico Palli, Monica Ferraroni, Zuo Feng Zhang, Guo Pei Yu, Nuno Lunet, Samantha Morais, Lizbeth López-Carrillo, David Zaridze, Dmitry Maximovitch, Marcela Guevara, Vanessa Santos-Sanchez, Jesus Vioque, Manoli Garcia de la Hera, Mary H. Ward, Reza MalekzadehMohammadreza Pakseresht, Raúl Ulises Hernández-Ramírez, Federica Turati, Charles S. Rabkin, Linda M. Liao, Rashmi Sinha, Malaquias López-Cervantes, Shoichiro Tsugane, Akihisa Hidaka, M. Constanza Camargo, Maria Paula Curado, Nadia Zubair, Dana Kristjansson, Shailja Shah, Carlo La Vecchia, Paolo Boffetta

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: Gastric cancer (GC) is among the leading causes of cancer mortality worldwide. The objective of this study was to investigate the association between dietary fiber intake and GC. Methods: We pooled data from 11 population or hospital-based case–control studies included in the Stomach Cancer Pooling (StoP) Project, for a total of 4865 histologically confirmed cases and 10,626 controls. Intake of dietary fibers and other dietary factors was collected using food frequency questionnaires. We calculated the odds ratios (OR) and 95% confidence intervals (CI) of the association between dietary fiber intake and GC by using a multivariable logistic regression model adjusted for study site, sex, age, caloric intake, smoking, fruit and vegetable intake, and socioeconomic status. We conducted stratified analyses by these factors, as well as GC anatomical site and histological type. Results: The OR of GC for an increase of one quartile of fiber intake was 0.91 (95% CI: 0.85, 0.97), that for the highest compared to the lowest quartile of dietary fiber intake was 0.72 (95% CI: 0.59, 0.88). Results were similar irrespective of anatomical site and histological type. Conclusion: Our analysis supports the hypothesis that dietary fiber intake may exert a protective effect on GC.

Original languageEnglish
JournalEuropean Journal of Nutrition
DOIs
StateAccepted/In press - 2024
Externally publishedYes

Keywords

  • Cardia
  • Dietary fiber
  • Fiber intake
  • Gastric cancer
  • Gastric neoplasm
  • Non-cardia

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