TY - JOUR
T1 - The association between autism spectrum disorder and psychotic experiences in the Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort
AU - Sullivan, Sarah
AU - Rai, Dheeraj
AU - Golding, Jean
AU - Zammit, Stan
AU - Steer, Colin
N1 - Funding Information:
The authors are extremely grateful to all the families who took part in this study, the midwives for their help in recruiting them, and the whole Avon Longitudinal Study of Parents and Children (ALSPAC) team, which includes interviewers, computer and laboratory technicians, clerical workers, research scientists, volunteers, managers, receptionists, and nurses. The UK MRC and the Wellcome Trust (grant 092731) and the University of Bristol provide core support for ALSPAC.
PY - 2013/8
Y1 - 2013/8
N2 - Objective: Studies report overlap between autism spectrum disorders and psychosis. This may indicate a relationship between the 2 disorders or an artificial overlap due to similarity of symptoms. The aim of this study was to investigate whether autism spectrum disorder and autistic traits predict psychotic experiences in early adolescence. Method: This study analyzes prospective data from a cohort. A dataset was analyzed of 5,359 cohort members who had provided data on autistic traits and/or a diagnosis of an autism spectrum disorder and psychotic experiences at age 12 years. Results: A diagnosis of an autism spectrum disorder (odds ratio = 2.81, 95% confidence interval = 1.07, 7.34 p =.035) and childhood autistic traits (odds ratio = 1.15, 95% confidence interval = 1.05, 1.26 p =.0018) were associated with psychotic experiences after adjustment for confounders. Conclusions: These findings suggest a shared neurodevelopmental origin for autism and psychosis.
AB - Objective: Studies report overlap between autism spectrum disorders and psychosis. This may indicate a relationship between the 2 disorders or an artificial overlap due to similarity of symptoms. The aim of this study was to investigate whether autism spectrum disorder and autistic traits predict psychotic experiences in early adolescence. Method: This study analyzes prospective data from a cohort. A dataset was analyzed of 5,359 cohort members who had provided data on autistic traits and/or a diagnosis of an autism spectrum disorder and psychotic experiences at age 12 years. Results: A diagnosis of an autism spectrum disorder (odds ratio = 2.81, 95% confidence interval = 1.07, 7.34 p =.035) and childhood autistic traits (odds ratio = 1.15, 95% confidence interval = 1.05, 1.26 p =.0018) were associated with psychotic experiences after adjustment for confounders. Conclusions: These findings suggest a shared neurodevelopmental origin for autism and psychosis.
KW - Avon Longitudinal Study of Parents and Children (ALSPAC)
KW - autism spectrum disorder
KW - birth cohort
KW - longitudinal
KW - psychotic experiences
UR - http://www.scopus.com/inward/record.url?scp=84880593445&partnerID=8YFLogxK
U2 - 10.1016/j.jaac.2013.05.010
DO - 10.1016/j.jaac.2013.05.010
M3 - Article
C2 - 23880491
AN - SCOPUS:84880593445
SN - 0890-8567
VL - 52
SP - 806-814.e2
JO - Journal of the American Academy of Child and Adolescent Psychiatry
JF - Journal of the American Academy of Child and Adolescent Psychiatry
IS - 8
ER -