Precision oncology is a novel research field and approach to cancer care which leverages high-throughput sequencing technologies and bioinformatics pipelines to determine diagnosis, prognosis, and treatment of patients in a personalized manner. This chapter provides an overview of a typical precision oncology software platform, from raw data to patient reports. Standard and advanced analytical components are described and discussed, along with their strengths and limitations, in general and in the context of a precision oncology application for advanced cancer patients.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
Number of pages22
StatePublished - 2022

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019


  • Actionable alterations
  • Biomarkers
  • Drug recommendations
  • High-throughput next-generation sequencing
  • Mutations
  • Patient reports
  • Precision oncology
  • RNA sequencing
  • Whole-exome sequencing
  • Whole-genome sequencing


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