The application of deep brain stimulation in the treatment of psychiatric disorders

Ilse Graat, Martijn Figee, Damiaan Denys

Research output: Contribution to journalReview articlepeer-review

70 Scopus citations


Deep brain stimulation (DBS) is a last-resort treatment for neurological and psychiatric disorders that are refractory to standard treatment. Over the last decades, the progress of DBS in psychiatry has been slower than in neurology, in part owing to the heterogenic symptomatology and complex neuroanatomy of psychiatric disorders. However, for obsessive-compulsive disorder (OCD) DBS is now an accepted treatment. This study first reviews clinical outcomes and mechanisms of DBS for OCD, and then discusses these results in an overview of current and future psychiatric applications, including DBS for mood disorders, Tourette’s syndrome, addiction, anorexia nervosa, autism, schizophrenia, and anxiety disorders. In addition, it will focus on novel techniques that may enhance the application of DBS in psychiatry.

Original languageEnglish
Pages (from-to)178-190
Number of pages13
JournalInternational Review of Psychiatry
Issue number2
StatePublished - 4 Mar 2017
Externally publishedYes


  • DBS
  • Deep brain stimulation
  • applications
  • psychiatry


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