The apolipoprotein(a) gene is regulated by sex hormones and acute–phase inducers in YAC transgenic mice

Kelly A. Frazer; Goutham Narla; Jun Li Zhang; Edward M. Rubin

doi:10.1038/ng0495-424

The apolipoprotein(a) gene is regulated by sex hormones and acute–phase inducers in YAC transgenic mice

Kelly A. Frazer, Goutham Narla, Jun Li Zhang, Edward M. Rubin

Research output: Contribution to journal › Article › peer-review

113 Scopus citations

Abstract

High plasma concentrations of apolipoprotein (a) (apo(a)) have been implicated as a major independent risk factor for atherosclerosis in humans. Apo(a) is a large, evolutionary new gene (present primarily in primates) for which considerable controversy exists concerning the factors that regulate its expression. To investigate the in vivo regulation of apo(a), we have created several lines of YAC transgenic mice containing a 110–kb human apo(a) gene surrounded by greater than 60 kb of 5′ and 3′ flanking DNA. Studies in humans have suggested that acute–phase inducers increase and sex steroids decrease apo(a) concentrations, but these results are controversial. Analysis of the YAC transgenic mice conclusively supports the hypothesized role of sex steroids and refutes the suggested role of acute–phase inducers in regulating the apo(a) gene.

Original language	English
Pages (from-to)	424-431
Number of pages	8
Journal	Nature Genetics
Volume	9
Issue number	4
DOIs	https://doi.org/10.1038/ng0495-424
State	Published - Apr 1995
Externally published	Yes

Access to Document

10.1038/ng0495-424

Cite this

@article{3450715f270743bcb2698be8391f498d,

title = "The apolipoprotein(a) gene is regulated by sex hormones and acute–phase inducers in YAC transgenic mice",

abstract = "High plasma concentrations of apolipoprotein (a) (apo(a)) have been implicated as a major independent risk factor for atherosclerosis in humans. Apo(a) is a large, evolutionary new gene (present primarily in primates) for which considerable controversy exists concerning the factors that regulate its expression. To investigate the in vivo regulation of apo(a), we have created several lines of YAC transgenic mice containing a 110–kb human apo(a) gene surrounded by greater than 60 kb of 5′ and 3′ flanking DNA. Studies in humans have suggested that acute–phase inducers increase and sex steroids decrease apo(a) concentrations, but these results are controversial. Analysis of the YAC transgenic mice conclusively supports the hypothesized role of sex steroids and refutes the suggested role of acute–phase inducers in regulating the apo(a) gene.",

author = "Frazer, {Kelly A.} and Goutham Narla and Zhang, {Jun Li} and Rubin, {Edward M.}",

year = "1995",

month = apr,

doi = "10.1038/ng0495-424",

language = "English",

volume = "9",

pages = "424--431",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Publishing Group",

number = "4",

}

TY - JOUR

T1 - The apolipoprotein(a) gene is regulated by sex hormones and acute–phase inducers in YAC transgenic mice

AU - Frazer, Kelly A.

AU - Narla, Goutham

AU - Zhang, Jun Li

AU - Rubin, Edward M.

PY - 1995/4

Y1 - 1995/4

N2 - High plasma concentrations of apolipoprotein (a) (apo(a)) have been implicated as a major independent risk factor for atherosclerosis in humans. Apo(a) is a large, evolutionary new gene (present primarily in primates) for which considerable controversy exists concerning the factors that regulate its expression. To investigate the in vivo regulation of apo(a), we have created several lines of YAC transgenic mice containing a 110–kb human apo(a) gene surrounded by greater than 60 kb of 5′ and 3′ flanking DNA. Studies in humans have suggested that acute–phase inducers increase and sex steroids decrease apo(a) concentrations, but these results are controversial. Analysis of the YAC transgenic mice conclusively supports the hypothesized role of sex steroids and refutes the suggested role of acute–phase inducers in regulating the apo(a) gene.

AB - High plasma concentrations of apolipoprotein (a) (apo(a)) have been implicated as a major independent risk factor for atherosclerosis in humans. Apo(a) is a large, evolutionary new gene (present primarily in primates) for which considerable controversy exists concerning the factors that regulate its expression. To investigate the in vivo regulation of apo(a), we have created several lines of YAC transgenic mice containing a 110–kb human apo(a) gene surrounded by greater than 60 kb of 5′ and 3′ flanking DNA. Studies in humans have suggested that acute–phase inducers increase and sex steroids decrease apo(a) concentrations, but these results are controversial. Analysis of the YAC transgenic mice conclusively supports the hypothesized role of sex steroids and refutes the suggested role of acute–phase inducers in regulating the apo(a) gene.

UR - http://www.scopus.com/inward/record.url?scp=0028920057&partnerID=8YFLogxK

U2 - 10.1038/ng0495-424

DO - 10.1038/ng0495-424

M3 - Article

C2 - 7795650

AN - SCOPUS:0028920057

SN - 1061-4036

VL - 9

SP - 424

EP - 431

JO - Nature Genetics

JF - Nature Genetics

IS - 4

ER -

The apolipoprotein(a) gene is regulated by sex hormones and acute–phase inducers in YAC transgenic mice

Abstract

Access to Document

Fingerprint

Cite this