The antiestrogen ly117018 blocks effects of estradiol on pituitary glucose-6-phosphate dehydrogenase specific activity and on serum lh

Marcia N. Gordon; Charles V. Mobbs; Caleb E. Finch

doi:10.1159/000124102

The antiestrogen ly117018 blocks effects of estradiol on pituitary glucose-6-phosphate dehydrogenase specific activity and on serum lh

Marcia N. Gordon, Charles V. Mobbs, Caleb E. Finch

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Neuroendocrine effects of the antiestrogen LY117018 were investigated in C57BL/6J mice. A series of subcutaneous injections of 17β-estradiol (E₂) into ovariectomized mice increased pituitary glucose-6-phosphate dehydrogenase (G6PDH) specific activity, increased uterine wet weight, and suppressed the postovariectomy rise in serum LH. Simultaneous administration of LY117018 completely reversed the effects of E₂ on G6PDH activity and uterine weight, and partially reversed the negative feedback of E₂ on luteinizing hormone (LH). When administered in the absence of E₂, LY117018 had no effect on G6PDH activity or serum LH, but increased uterine weight by 70%. Thus, LY117018 effectively antagonizes the effects of E₂ at both uterine and pituitary levels, but acts as a partial agonist only in the uterus.

Original language	English
Pages (from-to)	381-384
Number of pages	4
Journal	Neuroendocrinology
Volume	40
Issue number	5
DOIs	https://doi.org/10.1159/000124102
State	Published - 1985
Externally published	Yes

Keywords

Antiestrogen
Estradiol
Glucose-6-phosphate dehydrogenase
LY117018
Luteinizing hormone
Pituitary

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10.1159/000124102

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title = "The antiestrogen ly117018 blocks effects of estradiol on pituitary glucose-6-phosphate dehydrogenase specific activity and on serum lh",

abstract = "Neuroendocrine effects of the antiestrogen LY117018 were investigated in C57BL/6J mice. A series of subcutaneous injections of 17β-estradiol (E2) into ovariectomized mice increased pituitary glucose-6-phosphate dehydrogenase (G6PDH) specific activity, increased uterine wet weight, and suppressed the postovariectomy rise in serum LH. Simultaneous administration of LY117018 completely reversed the effects of E2 on G6PDH activity and uterine weight, and partially reversed the negative feedback of E2 on luteinizing hormone (LH). When administered in the absence of E2, LY117018 had no effect on G6PDH activity or serum LH, but increased uterine weight by 70%. Thus, LY117018 effectively antagonizes the effects of E2 at both uterine and pituitary levels, but acts as a partial agonist only in the uterus.",

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author = "Gordon, {Marcia N.} and Mobbs, {Charles V.} and Finch, {Caleb E.}",

year = "1985",

doi = "10.1159/000124102",

language = "English",

volume = "40",

pages = "381--384",

journal = "Neuroendocrinology",

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T1 - The antiestrogen ly117018 blocks effects of estradiol on pituitary glucose-6-phosphate dehydrogenase specific activity and on serum lh

AU - Gordon, Marcia N.

AU - Mobbs, Charles V.

AU - Finch, Caleb E.

PY - 1985

Y1 - 1985

N2 - Neuroendocrine effects of the antiestrogen LY117018 were investigated in C57BL/6J mice. A series of subcutaneous injections of 17β-estradiol (E2) into ovariectomized mice increased pituitary glucose-6-phosphate dehydrogenase (G6PDH) specific activity, increased uterine wet weight, and suppressed the postovariectomy rise in serum LH. Simultaneous administration of LY117018 completely reversed the effects of E2 on G6PDH activity and uterine weight, and partially reversed the negative feedback of E2 on luteinizing hormone (LH). When administered in the absence of E2, LY117018 had no effect on G6PDH activity or serum LH, but increased uterine weight by 70%. Thus, LY117018 effectively antagonizes the effects of E2 at both uterine and pituitary levels, but acts as a partial agonist only in the uterus.

AB - Neuroendocrine effects of the antiestrogen LY117018 were investigated in C57BL/6J mice. A series of subcutaneous injections of 17β-estradiol (E2) into ovariectomized mice increased pituitary glucose-6-phosphate dehydrogenase (G6PDH) specific activity, increased uterine wet weight, and suppressed the postovariectomy rise in serum LH. Simultaneous administration of LY117018 completely reversed the effects of E2 on G6PDH activity and uterine weight, and partially reversed the negative feedback of E2 on luteinizing hormone (LH). When administered in the absence of E2, LY117018 had no effect on G6PDH activity or serum LH, but increased uterine weight by 70%. Thus, LY117018 effectively antagonizes the effects of E2 at both uterine and pituitary levels, but acts as a partial agonist only in the uterus.

KW - Antiestrogen

KW - Estradiol

KW - Glucose-6-phosphate dehydrogenase

KW - LY117018

KW - Luteinizing hormone

KW - Pituitary

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IS - 5

ER -

The antiestrogen ly117018 blocks effects of estradiol on pituitary glucose-6-phosphate dehydrogenase specific activity and on serum lh

Abstract

Keywords

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