The Adaptive Immune Receptor Repertoire Knowledge Commons: An invitation to the community

Lindsay G. Cowell; Scott Christley; Felix Breden; Kevin A. Burns; Brian D. Corrie; William D. Lees; James A. Overton; Bjoern Peters; Eve Richardson; Krishna M. Roskin; Lonneke Scheffer; Randi Vita; Corey T. Watson; Gur Yaari

doi:10.1016/j.cels.2025.101401

The Adaptive Immune Receptor Repertoire Knowledge Commons: An invitation to the community

Lindsay G. Cowell
, Scott Christley
, Felix Breden
, Kevin A. Burns
, Brian D. Corrie
, William D. Lees
, James A. Overton
, Bjoern Peters
, Eve Richardson
, Krishna M. Roskin
, Lonneke Scheffer
, Randi Vita
, Corey T. Watson
, Gur Yaari

Research output: Contribution to journal › Comment/debate

2 Scopus citations

Abstract

Sequencing data elucidating adaptive immune receptor (AIR) repertoires, genomic loci encoding AIR genes, and AIR antigens are hosted in siloed repositories, limiting integrative analyses. We are in the process of creating the AIR Repertoire Knowledge Commons (AKC) by merging data from community-backed repositories and applying knowledge-generation algorithms to integrate and enrich data and metadata.

Original language	English
Article number	101401
Journal	Cell Systems
Volume	16
Issue number	9
DOIs	https://doi.org/10.1016/j.cels.2025.101401
State	Published - 17 Sep 2025
Externally published	Yes

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Cowell, L. G., Christley, S., Breden, F., Burns, K. A., Corrie, B. D., Lees, W. D., Overton, J. A., Peters, B., Richardson, E., Roskin, K. M., Scheffer, L., Vita, R., Watson, C. T., & Yaari, G. (2025). The Adaptive Immune Receptor Repertoire Knowledge Commons: An invitation to the community. Cell Systems, 16(9), Article 101401. https://doi.org/10.1016/j.cels.2025.101401

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title = "The Adaptive Immune Receptor Repertoire Knowledge Commons: An invitation to the community",

abstract = "Sequencing data elucidating adaptive immune receptor (AIR) repertoires, genomic loci encoding AIR genes, and AIR antigens are hosted in siloed repositories, limiting integrative analyses. We are in the process of creating the AIR Repertoire Knowledge Commons (AKC) by merging data from community-backed repositories and applying knowledge-generation algorithms to integrate and enrich data and metadata.",

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doi = "10.1016/j.cels.2025.101401",

language = "English",

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T2 - An invitation to the community

AU - Cowell, Lindsay G.

AU - Christley, Scott

AU - Breden, Felix

AU - Burns, Kevin A.

AU - Corrie, Brian D.

AU - Lees, William D.

AU - Overton, James A.

AU - Peters, Bjoern

AU - Richardson, Eve

AU - Roskin, Krishna M.

AU - Scheffer, Lonneke

AU - Vita, Randi

AU - Watson, Corey T.

AU - Yaari, Gur

PY - 2025/9/17

Y1 - 2025/9/17

N2 - Sequencing data elucidating adaptive immune receptor (AIR) repertoires, genomic loci encoding AIR genes, and AIR antigens are hosted in siloed repositories, limiting integrative analyses. We are in the process of creating the AIR Repertoire Knowledge Commons (AKC) by merging data from community-backed repositories and applying knowledge-generation algorithms to integrate and enrich data and metadata.

AB - Sequencing data elucidating adaptive immune receptor (AIR) repertoires, genomic loci encoding AIR genes, and AIR antigens are hosted in siloed repositories, limiting integrative analyses. We are in the process of creating the AIR Repertoire Knowledge Commons (AKC) by merging data from community-backed repositories and applying knowledge-generation algorithms to integrate and enrich data and metadata.

UR - https://www.scopus.com/pages/publications/105015609530

U2 - 10.1016/j.cels.2025.101401

DO - 10.1016/j.cels.2025.101401

M3 - Comment/debate

C2 - 40967183

AN - SCOPUS:105015609530

SN - 2405-4720

VL - 16

JO - Cell Systems

JF - Cell Systems

IS - 9

M1 - 101401

ER -

The Adaptive Immune Receptor Repertoire Knowledge Commons: An invitation to the community

Abstract

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