The 2017 IUIS Phenotypic Classification for Primary Immunodeficiencies

Aziz Bousfiha; Leïla Jeddane; Capucine Picard; Fatima Ailal; H. Bobby Gaspar; Waleed Al-Herz; Talal Chatila; Yanick J. Crow; Charlotte Cunningham-Rundles; Amos Etzioni; Jose Luis Franco; Steven M. Holland; Christoph Klein; Tomohiro Morio; Hans D. Ochs; Eric Oksenhendler; Jennifer Puck; Mimi L.K. Tang; Stuart G. Tangye; Troy R. Torgerson; Jean Laurent Casanova; Kathleen E. Sullivan

doi:10.1007/s10875-017-0465-8

The 2017 IUIS Phenotypic Classification for Primary Immunodeficiencies

Aziz Bousfiha, Leïla Jeddane, Capucine Picard, Fatima Ailal, H. Bobby Gaspar, Waleed Al-Herz, Talal Chatila, Yanick J. Crow, Charlotte Cunningham-Rundles, Amos Etzioni, Jose Luis Franco, Steven M. Holland, Christoph Klein, Tomohiro Morio, Hans D. Ochs, Eric Oksenhendler, Jennifer Puck, Mimi L.K. Tang, Stuart G. Tangye, Troy R. TorgersonJean Laurent Casanova, Kathleen E. Sullivan

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411 Scopus citations

Abstract

Since the 1990s, the International Union of Immunological Societies (IUIS) PID expert committee (EC), now called Inborn Errors of Immunity Committee, has published every other year a classification of the inborn errors of immunity. This complete catalog serves as a reference for immunologists and researchers worldwide. However, it was unadapted for clinicians at the bedside. For those, the IUIS PID EC is now publishing a phenotypical classification since 2013, which proved to be more user-friendly. There are now 320 single-gene inborn errors of immunity underlying phenotypes as diverse as infection, malignancy, allergy, auto-immunity, and auto-inflammation. We herein propose the revised 2017 phenotypic classification, based on the accompanying 2017 IUIS Inborn Errors of Immunity Committee classification.

Original language	English
Pages (from-to)	129-143
Number of pages	15
Journal	Journal of Clinical Immunology
Volume	38
Issue number	1
DOIs	https://doi.org/10.1007/s10875-017-0465-8
State	Published - 1 Jan 2018

Keywords

Classification
IUIS
Inborn errors of immunity
Phenotypic
Primary immunodeficiencies

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Bousfiha, A., Jeddane, L., Picard, C., Ailal, F., Bobby Gaspar, H., Al-Herz, W., Chatila, T., Crow, Y. J., Cunningham-Rundles, C., Etzioni, A., Franco, J. L., Holland, S. M., Klein, C., Morio, T., Ochs, H. D., Oksenhendler, E., Puck, J., Tang, M. L. K., Tangye, S. G., ... Sullivan, K. E. (2018). The 2017 IUIS Phenotypic Classification for Primary Immunodeficiencies. Journal of Clinical Immunology, 38(1), 129-143. https://doi.org/10.1007/s10875-017-0465-8

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title = "The 2017 IUIS Phenotypic Classification for Primary Immunodeficiencies",

abstract = "Since the 1990s, the International Union of Immunological Societies (IUIS) PID expert committee (EC), now called Inborn Errors of Immunity Committee, has published every other year a classification of the inborn errors of immunity. This complete catalog serves as a reference for immunologists and researchers worldwide. However, it was unadapted for clinicians at the bedside. For those, the IUIS PID EC is now publishing a phenotypical classification since 2013, which proved to be more user-friendly. There are now 320 single-gene inborn errors of immunity underlying phenotypes as diverse as infection, malignancy, allergy, auto-immunity, and auto-inflammation. We herein propose the revised 2017 phenotypic classification, based on the accompanying 2017 IUIS Inborn Errors of Immunity Committee classification.",

keywords = "Classification, IUIS, Inborn errors of immunity, Phenotypic, Primary immunodeficiencies",

author = "Aziz Bousfiha and Le{\"i}la Jeddane and Capucine Picard and Fatima Ailal and {Bobby Gaspar}, H. and Waleed Al-Herz and Talal Chatila and Crow, {Yanick J.} and Charlotte Cunningham-Rundles and Amos Etzioni and Franco, {Jose Luis} and Holland, {Steven M.} and Christoph Klein and Tomohiro Morio and Ochs, {Hans D.} and Eric Oksenhendler and Jennifer Puck and Tang, {Mimi L.K.} and Tangye, {Stuart G.} and Torgerson, {Troy R.} and Casanova, {Jean Laurent} and Sullivan, {Kathleen E.}",

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year = "2018",

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doi = "10.1007/s10875-017-0465-8",

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Bousfiha, A, Jeddane, L, Picard, C, Ailal, F, Bobby Gaspar, H, Al-Herz, W, Chatila, T, Crow, YJ, Cunningham-Rundles, C, Etzioni, A, Franco, JL, Holland, SM, Klein, C, Morio, T, Ochs, HD, Oksenhendler, E, Puck, J, Tang, MLK, Tangye, SG, Torgerson, TR, Casanova, JL & Sullivan, KE 2018, 'The 2017 IUIS Phenotypic Classification for Primary Immunodeficiencies', Journal of Clinical Immunology, vol. 38, no. 1, pp. 129-143. https://doi.org/10.1007/s10875-017-0465-8

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T1 - The 2017 IUIS Phenotypic Classification for Primary Immunodeficiencies

AU - Bousfiha, Aziz

AU - Jeddane, Leïla

AU - Picard, Capucine

AU - Ailal, Fatima

AU - Bobby Gaspar, H.

AU - Al-Herz, Waleed

AU - Chatila, Talal

AU - Crow, Yanick J.

AU - Cunningham-Rundles, Charlotte

AU - Etzioni, Amos

AU - Franco, Jose Luis

AU - Holland, Steven M.

AU - Klein, Christoph

AU - Morio, Tomohiro

AU - Ochs, Hans D.

AU - Oksenhendler, Eric

AU - Puck, Jennifer

AU - Tang, Mimi L.K.

AU - Tangye, Stuart G.

AU - Torgerson, Troy R.

AU - Casanova, Jean Laurent

AU - Sullivan, Kathleen E.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Since the 1990s, the International Union of Immunological Societies (IUIS) PID expert committee (EC), now called Inborn Errors of Immunity Committee, has published every other year a classification of the inborn errors of immunity. This complete catalog serves as a reference for immunologists and researchers worldwide. However, it was unadapted for clinicians at the bedside. For those, the IUIS PID EC is now publishing a phenotypical classification since 2013, which proved to be more user-friendly. There are now 320 single-gene inborn errors of immunity underlying phenotypes as diverse as infection, malignancy, allergy, auto-immunity, and auto-inflammation. We herein propose the revised 2017 phenotypic classification, based on the accompanying 2017 IUIS Inborn Errors of Immunity Committee classification.

AB - Since the 1990s, the International Union of Immunological Societies (IUIS) PID expert committee (EC), now called Inborn Errors of Immunity Committee, has published every other year a classification of the inborn errors of immunity. This complete catalog serves as a reference for immunologists and researchers worldwide. However, it was unadapted for clinicians at the bedside. For those, the IUIS PID EC is now publishing a phenotypical classification since 2013, which proved to be more user-friendly. There are now 320 single-gene inborn errors of immunity underlying phenotypes as diverse as infection, malignancy, allergy, auto-immunity, and auto-inflammation. We herein propose the revised 2017 phenotypic classification, based on the accompanying 2017 IUIS Inborn Errors of Immunity Committee classification.

KW - Classification

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SN - 0271-9142

VL - 38

SP - 129

EP - 143

JO - Journal of Clinical Immunology

JF - Journal of Clinical Immunology

IS - 1

ER -

The 2017 IUIS Phenotypic Classification for Primary Immunodeficiencies

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Keywords

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