TY - JOUR
T1 - The 2015 IUIS Phenotypic Classification for Primary Immunodeficiencies
AU - Bousfiha, Aziz
AU - Jeddane, Leïla
AU - Al-Herz, Waleed
AU - Ailal, Fatima
AU - Casanova, Jean Laurent
AU - Chatila, Talal
AU - Conley, Mary Ellen
AU - Cunningham‐Rundles, Charlotte
AU - Etzioni, Amos
AU - Franco, Jose Luis
AU - Gaspar, H. Bobby
AU - Holland, Steven M.
AU - Klein, Christoph
AU - Nonoyama, Shigeaki
AU - Ochs, Hans D.
AU - Oksenhendler, Eric
AU - Picard, Capucine
AU - Puck, Jennifer M.
AU - Sullivan, Kathleen E.
AU - Tang, Mimi L.K.
N1 - Publisher Copyright:
© 2015, Springer Science+Business Media New York.
PY - 2015/11/1
Y1 - 2015/11/1
N2 - There are now nearly 300 single-gene inborn errors of immunity underlying phenotypes as diverse as infection, malignancy, allergy, auto-immunity, and auto-inflammation. For each of these five categories, a growing variety of phenotypes are ascribed to Primary Immunodeficiency Diseases (PID), making PIDs a rapidly expanding field of medicine. The International Union of Immunological Societies (IUIS) PID expert committee (EC) has published every other year a classification of these disorders into tables, defined by shared pathogenesis and/or clinical consequences. In 2013, the IUIS committee also proposed a more user-friendly, phenotypic classification, based on the selection of key phenotypes at the bedside. We herein propose the revised figures, based on the accompanying 2015 IUIS PID EC classification.
AB - There are now nearly 300 single-gene inborn errors of immunity underlying phenotypes as diverse as infection, malignancy, allergy, auto-immunity, and auto-inflammation. For each of these five categories, a growing variety of phenotypes are ascribed to Primary Immunodeficiency Diseases (PID), making PIDs a rapidly expanding field of medicine. The International Union of Immunological Societies (IUIS) PID expert committee (EC) has published every other year a classification of these disorders into tables, defined by shared pathogenesis and/or clinical consequences. In 2013, the IUIS committee also proposed a more user-friendly, phenotypic classification, based on the selection of key phenotypes at the bedside. We herein propose the revised figures, based on the accompanying 2015 IUIS PID EC classification.
KW - IUIS PID expert committee
KW - Primary immunodeficiencies
KW - classification
UR - http://www.scopus.com/inward/record.url?scp=84948577653&partnerID=8YFLogxK
U2 - 10.1007/s10875-015-0198-5
DO - 10.1007/s10875-015-0198-5
M3 - Article
C2 - 26445875
AN - SCOPUS:84948577653
SN - 0271-9142
VL - 35
SP - 727
EP - 738
JO - Journal of Clinical Immunology
JF - Journal of Clinical Immunology
IS - 8
ER -