The 13p HSR in a human neuroblastoma cell line does not contain rRNA genes

Fred Gilbert, Abraham Grossman, Gloria Balaban, Roy Schmickel

Research output: Contribution to journalArticlepeer-review

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Abstract

We have studied a human neuroblastoma cell line containing a homogeneously staining region (HSR) on the short (p) arm of chromosome #13. The HSRs are believed to represent sites of gene amplification, containing multiple copies of one or a small number of genes. The 18S and 28S ribosomal RNA genes are the only structural genes so far assigned to the p arms of the human acrocentric chromosomes, which include number #13. Using two recombinant DNA probes specific for sequences in the 18S/28S ribosomal RNA (rRNA) gene complex for in situ hybridization, we have been able to establish that the 13pHSR in this line does not contain rRNA genes.

Original languageEnglish
Pages (from-to)113-119
Number of pages7
JournalCancer Genetics and Cytogenetics
Volume11
Issue number1
DOIs
StatePublished - Jan 1984

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