The δ-aminolevulinate dehydratase polymorphism: Higher blood lead levels in lead workers and environmentally exposed children with the 1-2 and 2-2 isozymes

James G. Wetmur; G. Lehnert; Robert J. Desnick

doi:10.1016/S0013-9351(05)80001-5

The δ-aminolevulinate dehydratase polymorphism: Higher blood lead levels in lead workers and environmentally exposed children with the 1-2 and 2-2 isozymes

James G. Wetmur, G. Lehnert, Robert J. Desnick

Research output: Contribution to journal › Article › peer-review

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Abstract

The erythrocyte δ-aminolevulinate dehydratase (ALAD) isozyme phenotypes and the blood lead levels were determined in a population of 202 lead factory workers in Germany and an environmentally exposed population of 1278 children in New York who had elevated free protoporphyrin levels. In both populations, individuals with the ALAD 1-2 or 2-2 isozyme phenotype had levels of blood lead statistically higher than those individuals with the ALAD 1-1 isozyme phenotype (lead workers: P > 0.004; children: P > 0.0001). Homozygotes and heterozygotes for the ALAD² allele who expressed the 2-2 or 1-2 isozyme phenotype had median blood lead levels that were about 9 to 11 μg/dl greater than similarly exposed individuals who were homozygous for the ALAD¹ allele. These findings support the hypothesis that the ALAD2 polypeptide binds lead more effectively, and therefore that individuals with the ALAD² allele may be more susceptible to lead poisoning.

Original language	English
Pages (from-to)	109-119
Number of pages	11
Journal	Environmental Research
Volume	56
Issue number	2
DOIs	https://doi.org/10.1016/S0013-9351(05)80001-5
State	Published - Dec 1991

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@article{1974cf15bfc74e1d9f69d052489be652,

title = "The δ-aminolevulinate dehydratase polymorphism: Higher blood lead levels in lead workers and environmentally exposed children with the 1-2 and 2-2 isozymes",

abstract = "The erythrocyte δ-aminolevulinate dehydratase (ALAD) isozyme phenotypes and the blood lead levels were determined in a population of 202 lead factory workers in Germany and an environmentally exposed population of 1278 children in New York who had elevated free protoporphyrin levels. In both populations, individuals with the ALAD 1-2 or 2-2 isozyme phenotype had levels of blood lead statistically higher than those individuals with the ALAD 1-1 isozyme phenotype (lead workers: P > 0.004; children: P > 0.0001). Homozygotes and heterozygotes for the ALAD2 allele who expressed the 2-2 or 1-2 isozyme phenotype had median blood lead levels that were about 9 to 11 μg/dl greater than similarly exposed individuals who were homozygous for the ALAD1 allele. These findings support the hypothesis that the ALAD2 polypeptide binds lead more effectively, and therefore that individuals with the ALAD2 allele may be more susceptible to lead poisoning.",

author = "Wetmur, \{James G.\} and G. Lehnert and Desnick, \{Robert J.\}",

note = "Funding Information: We thank Sylvan Wallenstein for his help in carrying out the statistical analysis. This research was supported by NIH Grants ES05046 (J.G.W.), DK34045 (R.J.D.), RR00077 (for the General Clinical Research Center from the Center for Research Resources, NIH) and a grant (15-131) from the March of Dimes Birth Defects Foundation.",

year = "1991",

month = dec,

doi = "10.1016/S0013-9351(05)80001-5",

language = "English",

volume = "56",

pages = "109--119",

journal = "Environmental Research",

issn = "0013-9351",

publisher = "Academic Press Inc.",

number = "2",

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T1 - The δ-aminolevulinate dehydratase polymorphism

T2 - Higher blood lead levels in lead workers and environmentally exposed children with the 1-2 and 2-2 isozymes

AU - Wetmur, James G.

AU - Lehnert, G.

AU - Desnick, Robert J.

N1 - Funding Information: We thank Sylvan Wallenstein for his help in carrying out the statistical analysis. This research was supported by NIH Grants ES05046 (J.G.W.), DK34045 (R.J.D.), RR00077 (for the General Clinical Research Center from the Center for Research Resources, NIH) and a grant (15-131) from the March of Dimes Birth Defects Foundation.

PY - 1991/12

Y1 - 1991/12

N2 - The erythrocyte δ-aminolevulinate dehydratase (ALAD) isozyme phenotypes and the blood lead levels were determined in a population of 202 lead factory workers in Germany and an environmentally exposed population of 1278 children in New York who had elevated free protoporphyrin levels. In both populations, individuals with the ALAD 1-2 or 2-2 isozyme phenotype had levels of blood lead statistically higher than those individuals with the ALAD 1-1 isozyme phenotype (lead workers: P > 0.004; children: P > 0.0001). Homozygotes and heterozygotes for the ALAD2 allele who expressed the 2-2 or 1-2 isozyme phenotype had median blood lead levels that were about 9 to 11 μg/dl greater than similarly exposed individuals who were homozygous for the ALAD1 allele. These findings support the hypothesis that the ALAD2 polypeptide binds lead more effectively, and therefore that individuals with the ALAD2 allele may be more susceptible to lead poisoning.

AB - The erythrocyte δ-aminolevulinate dehydratase (ALAD) isozyme phenotypes and the blood lead levels were determined in a population of 202 lead factory workers in Germany and an environmentally exposed population of 1278 children in New York who had elevated free protoporphyrin levels. In both populations, individuals with the ALAD 1-2 or 2-2 isozyme phenotype had levels of blood lead statistically higher than those individuals with the ALAD 1-1 isozyme phenotype (lead workers: P > 0.004; children: P > 0.0001). Homozygotes and heterozygotes for the ALAD2 allele who expressed the 2-2 or 1-2 isozyme phenotype had median blood lead levels that were about 9 to 11 μg/dl greater than similarly exposed individuals who were homozygous for the ALAD1 allele. These findings support the hypothesis that the ALAD2 polypeptide binds lead more effectively, and therefore that individuals with the ALAD2 allele may be more susceptible to lead poisoning.

UR - https://www.scopus.com/pages/publications/0026318695

U2 - 10.1016/S0013-9351(05)80001-5

DO - 10.1016/S0013-9351(05)80001-5

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AN - SCOPUS:0026318695

SN - 0013-9351

VL - 56

SP - 109

EP - 119

JO - Environmental Research

JF - Environmental Research

IS - 2

ER -

The δ-aminolevulinate dehydratase polymorphism: Higher blood lead levels in lead workers and environmentally exposed children with the 1-2 and 2-2 isozymes

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