Thalamocortical axons regulate neurogenesis and laminar fates in the early sensory cortex

Timothy Monko, Jaclyn Rebertus, Jeff Stolley, Stephen R. Salton, Yasushi Nakagawa

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Area-specific axonal projections from the mammalian thalamus shape unique cellular organization in target areas in the adult neocortex. How these axons control neurogenesis and early neuronal fate specification is poorly understood. By using mutant mice lacking the majority of thalamocortical axons, we show that these axons are required for the production and specification of the proper number of layer 4 neurons in primary sensory areas by the neonatal stage. Part of these area-specific roles is played by the thalamus-derived molecule, VGF. Our work reveals that extrinsic cues from sensory thalamic projections have an early role in the formation of cortical cytoarchitecture by enhancing the production and specification of layer 4 neurons.

Original languageEnglish
Article numbere2201355119
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number22
StatePublished - 31 May 2022


  • cell fate
  • neocortex
  • neurogenesis
  • thalamocortical


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