Th1, Th2 and Th17 inflammatory pathways synergistically predict cardiometabolic protein expression in serum of COVID-19 patients

James R. Michels, Mohammad Shaheed Nazrul, Sudeep Adhikari, Dawn Wilkins, Ana B. Pavel

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

A predominant source of complication in SARS-CoV-2 patients arises from a severe systemic inflammation that can lead to tissue damage and organ failure. The high inflammatory burden of this viral infection often results in cardiovascular comorbidities. A better understanding of the interaction between immune pathways and cardiovascular proteins might inform medical decisions and therapeutic approaches. In this study we hypothesized that helper T-cell inflammatory pathways (Th1, Th2 and Th17) synergistically correlate with cardiometabolic proteins in serum of COVID-19 patients. We found that Th1, Th2 and Th17 cytokines and chemokines are able to predict expression of 186 cardiometabolic proteins profiled by Olink proteomics.

Original languageEnglish
Pages (from-to)408-416
Number of pages9
JournalMolecular Omics
Volume18
Issue number5
DOIs
StatePublished - 7 Mar 2022
Externally publishedYes

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