TGF-β signaling dictates apoptotic and angiogenic response during prostate cancer progression

Natasha Kyprianou; Joanne Collazo

doi:10.2174/978160805007911001010209

TGF-β signaling dictates apoptotic and angiogenic response during prostate cancer progression

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

A number of reports implicated targeting TGF-β as a promising therapeutic target for the treatment of many types of cancer including prostate cancer. This cytokine not only have the ability to suppress cancer cell growth and proliferation during the early stage of cancer but to promote tumor progression and metastasis during the advance stage of disease. The elucidation of mechanism responsible for the TGF-β switch for a tumor suppressor to tumor promoting cytokine is critical for implementation of TGF-β as a promising therapeutic target for advanced stage of cancer towards tumor progression and metastasis.

Original language	English
Title of host publication	Angiogenesis & Therapeutic Targets In Cancer
Publisher	Bentham Science Publishers Ltd.
Pages	209-218
Number of pages	10
ISBN (Print)	9781608055739
DOIs	https://doi.org/10.2174/978160805007911001010209
State	Published - 2010
Externally published	Yes

Keywords

Androgens
Apoptosis
Metastasis
Prostate cancer
Smad-signaling
TGF-β

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10.2174/978160805007911001010209

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KW - Apoptosis

KW - Metastasis

KW - Prostate cancer

KW - Smad-signaling

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TGF-β signaling dictates apoptotic and angiogenic response during prostate cancer progression

Abstract

Keywords

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