TY - JOUR
T1 - Textures of the tumour microenvironment
AU - Di Martino, Julie S.
AU - Mondal, Chandrani
AU - Bravo-Cordero, Jose Javier
N1 - Funding Information:
We would like to thank Gb Kim (http://www.gbkim.com/) for sharing her artistic representations of the TME with us (Figure 1 and 3) and the Microscopy CoRE at Mount Sinai. This work was supported by the Susan G. Komen Career Catalyst Research [grant number CCR18547848]; the NCI Career Transition Award [grant number K22CA196750]; the Tisch Cancer Institute NIH Cancer Center Grant [grant number P30-CA196521]; the Schneider-Lesser Foundation Award; the Stony Brook-Mount Sinai Pilot Award [grant number PP21 ]; and the NIH T32 CA078207 Training Program in Cancer Biology [grant number CA078207 (to C.M.)].
Funding Information:
This work was supported by the Susan G. Komen Career Catalyst Research [grant number CCR18547848]; the NCI Career Transition Award [grant number K22CA196750]; the Tisch Cancer Institute NIH Cancer Center Grant [grant number P30-CA196521]; the Schneider-Lesser Foundation Award; the Stony Brook-Mount Sinai Pilot Award [grant number PP21 ]; and the NIH T32 CA078207 Training Program in Cancer Biology [grant number CA078207 (to C.M.)].
Publisher Copyright:
© 2019 The Author(s).
PY - 2019
Y1 - 2019
N2 - In this review, we present recent findings on the dynamic nature of the tumour microenvironment (TME) and how intravital microscopy studies have defined TME components in a spatiotemporal manner. Intravital microscopy has shed light into the nature of the TME, revealing structural details of both tumour cells and other TME co-habitants in vivo, how these cells communicate with each other, and how they are organized in three-dimensional space to orchestrate tumour growth, invasion, dissemination and metastasis. We will review different imaging tools, imaging reporters and fate-mapping strategies that have begun to uncover the complexity of the TME in vivo.
AB - In this review, we present recent findings on the dynamic nature of the tumour microenvironment (TME) and how intravital microscopy studies have defined TME components in a spatiotemporal manner. Intravital microscopy has shed light into the nature of the TME, revealing structural details of both tumour cells and other TME co-habitants in vivo, how these cells communicate with each other, and how they are organized in three-dimensional space to orchestrate tumour growth, invasion, dissemination and metastasis. We will review different imaging tools, imaging reporters and fate-mapping strategies that have begun to uncover the complexity of the TME in vivo.
UR - http://www.scopus.com/inward/record.url?scp=85074377221&partnerID=8YFLogxK
U2 - 10.1042/EBC20190019
DO - 10.1042/EBC20190019
M3 - Review article
C2 - 31654075
AN - SCOPUS:85074377221
SN - 0071-1365
VL - 63
SP - 619
EP - 629
JO - Essays in Biochemistry
JF - Essays in Biochemistry
IS - 5
ER -