Tethered neoantigens from the dead sculpt tumor fate

J. Magarian Blander; Atimukta Jha

doi:10.1038/s41590-025-02367-5

Tethered neoantigens from the dead sculpt tumor fate

J. Magarian Blander
, Atimukta Jha

Research output: Contribution to journal › Comment/debate

Abstract

New data show that DNGR-1 enables type 1 conventional dendritic cells to sculpt cancer immunoediting through selective cross-presentation of F-actin-tethered neoantigens, enriching tumors for immune-evasive variants.

Original language	English
Pages (from-to)	7-9
Number of pages	3
Journal	Nature Immunology
Volume	27
Issue number	1
DOIs	https://doi.org/10.1038/s41590-025-02367-5
State	Published - Jan 2026
Externally published	Yes

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title = "Tethered neoantigens from the dead sculpt tumor fate",

abstract = "New data show that DNGR-1 enables type 1 conventional dendritic cells to sculpt cancer immunoediting through selective cross-presentation of F-actin-tethered neoantigens, enriching tumors for immune-evasive variants.",

author = "Blander, \{J. Magarian\} and Atimukta Jha",

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doi = "10.1038/s41590-025-02367-5",

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N2 - New data show that DNGR-1 enables type 1 conventional dendritic cells to sculpt cancer immunoediting through selective cross-presentation of F-actin-tethered neoantigens, enriching tumors for immune-evasive variants.

AB - New data show that DNGR-1 enables type 1 conventional dendritic cells to sculpt cancer immunoediting through selective cross-presentation of F-actin-tethered neoantigens, enriching tumors for immune-evasive variants.

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DO - 10.1038/s41590-025-02367-5

M3 - Comment/debate

C2 - 41482543

AN - SCOPUS:105026363713

SN - 1529-2908

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JO - Nature Immunology

JF - Nature Immunology

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Tethered neoantigens from the dead sculpt tumor fate

Abstract

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