Test–retest reliability of a stimulation-locked evoked response to deep brain stimulation in subcallosal cingulate for treatment resistant depression

Allison C. Waters, Ashan Veerakumar, Ki Sueng Choi, Bryan Howell, Vineet Tiruvadi, Kelly R. Bijanki, Andrea Crowell, Patricio Riva-Posse, Helen S. Mayberg

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Deep brain stimulation (DBS) to the subcallosal cingulate cortex (SCC) is an emerging therapy for treatment resistant depression. Precision targeting of specific white matter fibers is now central to the model of SCC DBS treatment efficacy. A method to confirm SCC DBS target engagement is needed to reduce procedural variance across treatment providers and to optimize DBS parameters for individual patients. We examined the reliability of a novel cortical evoked response that is time-locked to a 2 Hz DBS pulse and shows the propagation of signal from the DBS target. The evoked response was detected in four individuals as a stereotyped series of components within 150 ms of a 6 V DBS pulse, each showing coherent topography on the head surface. Test–retest reliability across four repeated measures over 14 months met or exceeded standards for valid test construction in three of four patients. Several observations in this pilot sample demonstrate the prospective utility of this method to confirm surgical target engagement and instruct parameter selection. The topography of an orbital frontal component on the head surface showed specificity for patterns of forceps minor activation, which may provide a means to confirm DBS location with respect to key white matter structures. A divergent cortical response to unilateral stimulation of left (vs. right) hemisphere underscores the need for feedback acuity on the level of a single electrode, despite bilateral presentation of therapeutic stimulation. Results demonstrate viability of this method to explore patient-specific cortical responsivity to DBS for brain-circuit pathologies.

Original languageEnglish
Pages (from-to)4844-4856
Number of pages13
JournalHuman Brain Mapping
Volume39
Issue number12
DOIs
StatePublished - Dec 2018

Keywords

  • cortico-cortical evoked potential
  • deep brain stimulation
  • forceps minor
  • stimulation evoked potential
  • subcallosal cingulate cortex
  • treatment resistant depression
  • white matter tractography

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