Terahertz spectroscopy of bound water in nano suspensions

S. P. Mickan; J. Dordick; J. Munch; D. Abbott; X. C. Zhang

doi:10.1117/12.477384

Terahertz spectroscopy of bound water in nano suspensions

S. P. Mickan, J. Dordick, J. Munch, D. Abbott, X. C. Zhang

Research output: Contribution to journal › Conference article › peer-review

16 Scopus citations

Abstract

The study of enzymatic protein molecules using terahertz time-domain spectroscopy (THz-TDS) has the potential to reveal molecular activity in real time without the use of labelling. Molecular hydration, or bound water, is a critical parameter in enzyme activity and THz-TDS measurements. For the first time we experimentally measure the terahertz-frequency response of nano-sized particles of protein and their level of molecular hydration. These measurements are valuable in understanding the terahertz response of biological systems and in studying the interaction between bound water and proteins.

Original language	English
Pages (from-to)	49-61
Number of pages	13
Journal	Proceedings of SPIE - The International Society for Optical Engineering
Volume	4937
DOIs	https://doi.org/10.1117/12.477384
State	Published - 2002
Externally published	Yes
Event	Biomedical Applications of Micro- and Nanoengineering - Melbourne, VIC., Australia Duration: 16 Dec 2002 → 18 Dec 2002

Keywords

1,4-dioxane
Bound water
FIR dielectric
Organic solvent
Terahertz time-domain spectroscopy
Ultrafast

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10.1117/12.477384

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title = "Terahertz spectroscopy of bound water in nano suspensions",

abstract = "The study of enzymatic protein molecules using terahertz time-domain spectroscopy (THz-TDS) has the potential to reveal molecular activity in real time without the use of labelling. Molecular hydration, or bound water, is a critical parameter in enzyme activity and THz-TDS measurements. For the first time we experimentally measure the terahertz-frequency response of nano-sized particles of protein and their level of molecular hydration. These measurements are valuable in understanding the terahertz response of biological systems and in studying the interaction between bound water and proteins.",

keywords = "1,4-dioxane, Bound water, FIR dielectric, Organic solvent, Terahertz time-domain spectroscopy, Ultrafast",

author = "Mickan, \{S. P.\} and J. Dordick and J. Munch and D. Abbott and Zhang, \{X. C.\}",

year = "2002",

doi = "10.1117/12.477384",

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volume = "4937",

pages = "49--61",

journal = "Proceedings of SPIE - The International Society for Optical Engineering",

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note = "Biomedical Applications of Micro- and Nanoengineering ; Conference date: 16-12-2002 Through 18-12-2002",

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TY - JOUR

T1 - Terahertz spectroscopy of bound water in nano suspensions

AU - Mickan, S. P.

AU - Dordick, J.

AU - Munch, J.

AU - Abbott, D.

AU - Zhang, X. C.

PY - 2002

Y1 - 2002

N2 - The study of enzymatic protein molecules using terahertz time-domain spectroscopy (THz-TDS) has the potential to reveal molecular activity in real time without the use of labelling. Molecular hydration, or bound water, is a critical parameter in enzyme activity and THz-TDS measurements. For the first time we experimentally measure the terahertz-frequency response of nano-sized particles of protein and their level of molecular hydration. These measurements are valuable in understanding the terahertz response of biological systems and in studying the interaction between bound water and proteins.

AB - The study of enzymatic protein molecules using terahertz time-domain spectroscopy (THz-TDS) has the potential to reveal molecular activity in real time without the use of labelling. Molecular hydration, or bound water, is a critical parameter in enzyme activity and THz-TDS measurements. For the first time we experimentally measure the terahertz-frequency response of nano-sized particles of protein and their level of molecular hydration. These measurements are valuable in understanding the terahertz response of biological systems and in studying the interaction between bound water and proteins.

KW - 1,4-dioxane

KW - Bound water

KW - FIR dielectric

KW - Organic solvent

KW - Terahertz time-domain spectroscopy

KW - Ultrafast

UR - https://www.scopus.com/pages/publications/0037627463

U2 - 10.1117/12.477384

DO - 10.1117/12.477384

M3 - Conference article

AN - SCOPUS:0037627463

SN - 0277-786X

VL - 4937

SP - 49

EP - 61

JO - Proceedings of SPIE - The International Society for Optical Engineering

JF - Proceedings of SPIE - The International Society for Optical Engineering

T2 - Biomedical Applications of Micro- and Nanoengineering

Y2 - 16 December 2002 through 18 December 2002

ER -

Terahertz spectroscopy of bound water in nano suspensions

Abstract

Keywords

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