Tendon rupture associated with concomitant simvastatin and gemfibrozil use: Biological and pharmacokinetic implications

Edison Jose Cano Cevallos; Danial Haris Shaikh; Jose Gonzalez; William Sanchez; Madanmohan Patel

doi:10.1002/ccr3.2387

Tendon rupture associated with concomitant simvastatin and gemfibrozil use: Biological and pharmacokinetic implications

Edison Jose Cano Cevallos
, Danial Haris Shaikh
, Jose Gonzalez
, William Sanchez
, Madanmohan Patel

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Tendon or muscle rupture is a rare complication of statins that could potentially be disabling and result in a significant burden to patients. The co-administration of statin and gemfibrozil should warrant prescribers’ awareness of tendon-related complications of statin use, particularly in high-risk populations with poor renal function or musculoskeletal comorbidities.

Original language	English
Pages (from-to)	1919-1922
Number of pages	4
Journal	Clinical Case Reports
Volume	7
Issue number	10
DOIs	https://doi.org/10.1002/ccr3.2387
State	Published - 1 Oct 2019
Externally published	Yes

Keywords

adverse effects
gemfibrozil
muscle rupture
statin
tendon rupture

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10.1002/ccr3.2387

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title = "Tendon rupture associated with concomitant simvastatin and gemfibrozil use: Biological and pharmacokinetic implications",

abstract = "Tendon or muscle rupture is a rare complication of statins that could potentially be disabling and result in a significant burden to patients. The co-administration of statin and gemfibrozil should warrant prescribers{\textquoteright} awareness of tendon-related complications of statin use, particularly in high-risk populations with poor renal function or musculoskeletal comorbidities.",

keywords = "adverse effects, gemfibrozil, muscle rupture, statin, tendon rupture",

author = "\{Cano Cevallos\}, \{Edison Jose\} and Shaikh, \{Danial Haris\} and Jose Gonzalez and William Sanchez and Madanmohan Patel",

note = "Publisher Copyright: {\textcopyright} 2019 The Authors. Clinical Case Reports published by John Wiley \& Sons Ltd.",

year = "2019",

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T1 - Tendon rupture associated with concomitant simvastatin and gemfibrozil use

T2 - Biological and pharmacokinetic implications

AU - Cano Cevallos, Edison Jose

AU - Shaikh, Danial Haris

AU - Gonzalez, Jose

AU - Sanchez, William

AU - Patel, Madanmohan

PY - 2019/10/1

Y1 - 2019/10/1

N2 - Tendon or muscle rupture is a rare complication of statins that could potentially be disabling and result in a significant burden to patients. The co-administration of statin and gemfibrozil should warrant prescribers’ awareness of tendon-related complications of statin use, particularly in high-risk populations with poor renal function or musculoskeletal comorbidities.

AB - Tendon or muscle rupture is a rare complication of statins that could potentially be disabling and result in a significant burden to patients. The co-administration of statin and gemfibrozil should warrant prescribers’ awareness of tendon-related complications of statin use, particularly in high-risk populations with poor renal function or musculoskeletal comorbidities.

KW - adverse effects

KW - gemfibrozil

KW - muscle rupture

KW - statin

KW - tendon rupture

UR - https://www.scopus.com/pages/publications/85071314591

U2 - 10.1002/ccr3.2387

DO - 10.1002/ccr3.2387

M3 - Article

AN - SCOPUS:85071314591

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VL - 7

SP - 1919

EP - 1922

JO - Clinical Case Reports

JF - Clinical Case Reports

IS - 10

ER -

Tendon rupture associated with concomitant simvastatin and gemfibrozil use: Biological and pharmacokinetic implications

Abstract

Keywords

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