Temporal relationship between elevated blood pressure and arterial stiffening among middle-aged black and white adults

Wei Chen, Shengxu Li, Camilo Fernandez, Dianjianyi Sun, Chin Chih Lai, Tao Zhang, Lydia Bazzano, Elaine M. Urbina, Hong Wen Deng

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54 Scopus citations

Abstract

This study assessed the temporal relationship between elevated blood pressure (BP) and arterial stiffness in a biracial (black-white) cohort of middle-aged adults aged 32-51 years from the semirural community of Bogalusa, Louisiana. Measurements of aortic-femoral pulse wave velocity (afPWV; n = 446) and large- and small-arterial compliance (n = 381) were obtained at 2 time points between 2000 and 2010, with an average follow-up period of 7 years. A cross-lagged path analysis model was used to examine the temporal relationship of elevated BP to arterial stiffness and elasticity. The cross-lagged path coefficients did not differ significantly between blacks and whites. The path coefficient (ρ2) from baseline BP to follow-up afPWV was significantly greater than the path coefficient (ρ1) from baseline afPWV to follow-up BP (ρ2 = 0.20 vs. ρ1 = 0.07 (P = 0.048) for systolic BP; ρ2 = 0.19 vs. ρ1 = 0.05 (P = 0.034) for diastolic BP). The results for this 1-directional path from baseline BP to follow-up afPWV were confirmed, although marginally significant, by using large- and small-artery elasticity measurements. These findings provide strong evidence that elevated BP precedes large-artery stiffening in middle-aged adults. Unlike the case in older adults, the large-arterial wall is not stiff enough in youth to alter BP levels during young adulthood.

Original languageEnglish
Pages (from-to)599-608
Number of pages10
JournalAmerican Journal of Epidemiology
Volume183
Issue number7
DOIs
StatePublished - 1 Apr 2016
Externally publishedYes

Keywords

  • arterial elasticity
  • arterial stiffness
  • blood pressure
  • longitudinal analysis
  • temporal relationships

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