Temporal Immunomodulation via Wireless Programmed Electric Cues Achieves Optimized Diabetic Bone Regeneration

Jiwei Sun, Danlei Zhao, Yifan Wang, Ping Chen, Chao Xu, Haoqi Lei, Keqi Wo, Junyuan Zhang, Jinyu Wang, Cheng Yang, Bin Su, Zuolin Jin, Zhiqiang Luo, Lili Chen

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Mimicking the temporal pattern of biological behaviors during the natural repair process is a promising strategy for biomaterial-mediated tissue regeneration. However, precise regulation of dynamic cell behaviors allocated in a microenvironment post-implantation remains challenging until now. Here, remote tuning of electric cues is accomplished by wireless ultrasound stimulation (US) on an electroactive membrane for bone regeneration under a diabetic background. Programmable electric cues mediated by US from the piezoelectric membrane achieve the temporal regulation of macrophage polarization, satisfying the pattern of immunoregulation during the natural healing process and effectively promoting diabetic bone repair. Mechanistic insight reveals that the controllable decrease in AKT2 expression and phosphorylation could explain US-mediated macrophage polarization. This study exhibits a strategy aimed at precisely biosimulating the temporal regenerative pattern by controllable and programmable electric output for optimized diabetic tissue regeneration and provides basic insights into bionic design-based precision medicine achieved by intelligent and external field-responsive biomaterials.

Original languageEnglish
Pages (from-to)22830-22843
Number of pages14
JournalACS Nano
Volume17
Issue number22
DOIs
StatePublished - 28 Nov 2023
Externally publishedYes

Keywords

  • diabetic bone defect
  • improved bone regeneration
  • piezoelectric membranes
  • temporal immunomodulation
  • wireless electric cues

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