Temporal emergence of age-associated changes in cognitive and physical function in vervets (Chlorocebus aethiops sabaeus)

Brett M. Frye, Payton M. Valure, Suzanne Craft, Mark G. Baxter, Christie Scott, Shanna Wise-Walden, David W. Bissinger, Hannah M. Register, Carson Copeland, Matthew J. Jorgensen, Jamie N. Justice, Stephen B. Kritchevsky, Thomas C. Register, Carol A. Shively

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Dual declines in gait speed and cognitive performance are associated with increased risk of developing dementia. Characterizing the patterns of such impairments therefore is paramount to distinguishing healthy from pathological aging. Nonhuman primates such as vervet/African green monkeys (Chlorocebus aethiops sabaeus) are important models of human neurocognitive aging, yet the trajectory of dual decline has not been characterized. We therefore (1) assessed whether cognitive and physical performance (i.e., gait speed) are lower in older aged animals; (2) explored the relationship between performance in a novel task of executive function (Wake Forest Maze Task—WFMT) and a well-established assessment of working memory (delayed response task—DR task); and (3) examined the association between baseline gait speed with executive function and working memory at 1-year follow-up. We found (1) physical and cognitive declines with age; (2) strong agreement between performance in the novel WFMT and DR task; and (3) that slow gait is associated with poor cognitive performance in both domains. Our results suggest that older aged vervets exhibit a coordinated suite of traits consistent with human aging and that slow gait may be a biomarker of cognitive decline. This integrative approach provides evidence that gait speed and cognitive function differ across the lifespan in female vervet monkeys, which advances them as a model that could be used to dissect relationships between trajectories of dual decline over time.

Original languageEnglish
Pages (from-to)1303-1315
Number of pages13
Issue number3
StatePublished - Jun 2021
Externally publishedYes


  • Alzheimer’s disease
  • Executive function
  • Gait speed
  • Nonhuman primate
  • Working memory


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