Abstract
The in vivo biologic activities of a clonal isolate of the Rauscher strain of murine leukemia virus and several conditional lethal mutants with impaired replicative functions at the non‐permissive temperature were investigated. The parental virus induced a rapidly developing lymphoid leukemia in a high percentage of NIH Swiss mice inoculated as newborns. Mice inoculated in parallel with temperature‐sensitive mutant viruses showed no evidence of disease. The implications of these findings with regard to the requirements for type‐C virus replication to permit oncogenic transformation of lymphoid cells in vivo are discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 1009-1015 |
| Number of pages | 7 |
| Journal | International Journal of Cancer |
| Volume | 15 |
| Issue number | 6 |
| DOIs | |
| State | Published - 15 Jun 1975 |
| Externally published | Yes |