Telomere shortening in T lymphocytes of older individuals with Down syndrome and dementia

Edmund C. Jenkins; Milen T. Velinov; Lingling Ye; Hong Gu; Shuyun Li; Edmund C. Jenkins; Susan Sklower Brooks; Deborah Pang; Darlynne A. Devenny; Warren B. Zigman; Nicole Schupf; Wayne P. Silverman

doi:10.1016/j.neurobiolaging.2005.05.021

Telomere shortening in T lymphocytes of older individuals with Down syndrome and dementia

Edmund C. Jenkins, Milen T. Velinov, Lingling Ye, Hong Gu, Shuyun Li, Edmund C. Jenkins, Susan Sklower Brooks, Deborah Pang, Darlynne A. Devenny, Warren B. Zigman, Nicole Schupf, Wayne P. Silverman

Research output: Contribution to journal › Article › peer-review

73 Scopus citations

Abstract

Telomere shortening has been recently correlated with Alzheimer's disease status. Therefore, we hypothesized that a possible association might exist for adults with Down syndrome (DS). Using blind, quantitative telomere protein nucleic acid FISH analyses of metaphase and interphase preparations from 18 age-matched trisomy 21 female study participants with and without dementia, we have observed increased telomere shortening in adults with DS and dementia (p < .01). From this initial study, we conclude that telomere shortening is associated with dementia in this high-risk population and suggest that additional research may show that telomere shortening may be a biological marker of dementia status.

Original language	English
Pages (from-to)	941-945
Number of pages	5
Journal	Neurobiology of Aging
Volume	27
Issue number	7
DOIs	https://doi.org/10.1016/j.neurobiolaging.2005.05.021
State	Published - Jul 2006
Externally published	Yes

Keywords

Dementia
Down syndrome
FISH
Interphase
Metaphase
Telomere shortening

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10.1016/j.neurobiolaging.2005.05.021

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title = "Telomere shortening in T lymphocytes of older individuals with Down syndrome and dementia",

abstract = "Telomere shortening has been recently correlated with Alzheimer's disease status. Therefore, we hypothesized that a possible association might exist for adults with Down syndrome (DS). Using blind, quantitative telomere protein nucleic acid FISH analyses of metaphase and interphase preparations from 18 age-matched trisomy 21 female study participants with and without dementia, we have observed increased telomere shortening in adults with DS and dementia (p < .01). From this initial study, we conclude that telomere shortening is associated with dementia in this high-risk population and suggest that additional research may show that telomere shortening may be a biological marker of dementia status.",

keywords = "Dementia, Down syndrome, FISH, Interphase, Metaphase, Telomere shortening",

author = "Jenkins, \{Edmund C.\} and Velinov, \{Milen T.\} and Lingling Ye and Hong Gu and Shuyun Li and Jenkins, \{Edmund C.\} and Brooks, \{Susan Sklower\} and Deborah Pang and Devenny, \{Darlynne A.\} and Zigman, \{Warren B.\} and Nicole Schupf and Silverman, \{Wayne P.\}",

year = "2006",

month = jul,

doi = "10.1016/j.neurobiolaging.2005.05.021",

language = "English",

volume = "27",

pages = "941--945",

journal = "Neurobiology of Aging",

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publisher = "Elsevier Inc.",

number = "7",

}

TY - JOUR

T1 - Telomere shortening in T lymphocytes of older individuals with Down syndrome and dementia

AU - Jenkins, Edmund C.

AU - Velinov, Milen T.

AU - Ye, Lingling

AU - Gu, Hong

AU - Li, Shuyun

AU - Jenkins, Edmund C.

AU - Brooks, Susan Sklower

AU - Pang, Deborah

AU - Devenny, Darlynne A.

AU - Zigman, Warren B.

AU - Schupf, Nicole

AU - Silverman, Wayne P.

PY - 2006/7

Y1 - 2006/7

N2 - Telomere shortening has been recently correlated with Alzheimer's disease status. Therefore, we hypothesized that a possible association might exist for adults with Down syndrome (DS). Using blind, quantitative telomere protein nucleic acid FISH analyses of metaphase and interphase preparations from 18 age-matched trisomy 21 female study participants with and without dementia, we have observed increased telomere shortening in adults with DS and dementia (p < .01). From this initial study, we conclude that telomere shortening is associated with dementia in this high-risk population and suggest that additional research may show that telomere shortening may be a biological marker of dementia status.

AB - Telomere shortening has been recently correlated with Alzheimer's disease status. Therefore, we hypothesized that a possible association might exist for adults with Down syndrome (DS). Using blind, quantitative telomere protein nucleic acid FISH analyses of metaphase and interphase preparations from 18 age-matched trisomy 21 female study participants with and without dementia, we have observed increased telomere shortening in adults with DS and dementia (p < .01). From this initial study, we conclude that telomere shortening is associated with dementia in this high-risk population and suggest that additional research may show that telomere shortening may be a biological marker of dementia status.

KW - Dementia

KW - Down syndrome

KW - FISH

KW - Interphase

KW - Metaphase

KW - Telomere shortening

UR - https://www.scopus.com/pages/publications/33646510788

U2 - 10.1016/j.neurobiolaging.2005.05.021

DO - 10.1016/j.neurobiolaging.2005.05.021

M3 - Article

C2 - 16046031

AN - SCOPUS:33646510788

SN - 0197-4580

VL - 27

SP - 941

EP - 945

JO - Neurobiology of Aging

JF - Neurobiology of Aging

IS - 7

ER -

Telomere shortening in T lymphocytes of older individuals with Down syndrome and dementia

Abstract

Keywords

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