Personalized exercise interventions comprising aerobic, resistance and corrective therapeutic components were shown to result in endurance and strength improvement and reduction of fatigue and spasticity in patients with multiple sclerosis (PwMS). However, telerehabilitation support of multipronged exercise programs in PwMS has received limited attention. The goal of this project was to introduce telerehabilitation support of individualized multipronged exercise programs and to assess feasibility assessment of the initial prototype in PwMS. Feasibility was assessed in 10 PwMS who were asked to perform a standardized set of tasks essential for using the telerehabilitation system independently and score each task. Our results indicated high level of acceptance of the system by these patients. On average, it took about 1-2 minutes for the patients to complete the study tasks essential for system operation. They were able to successfully use the system and follow their individualized exercise prescription. The resulting system will have to undergo a definitive systematic evaluation in a randomized controlled trial to demonstrate its clinical impact.