Technology Insight: Querying the genome with microarrays - Progress and hope for neurological disease

Giovanni Coppola, Daniel H. Geschwind

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations

Abstract

The ability to perform large-scale analysis of the genome at the level of gene sequence, gene copy number and messenger RNA transcript expression characterizes the post-genomic era. In the past decade, the microarray-based approach has emerged as one of the major tools in this area of genome biology, contributing to advances in the understanding of Mendelian and complex neurological disorders. Despite technical issues regarding design, data analysis and validation that have to be addressed in the planning and interpretation of a microarray study, microarray-based approaches for studying transcript expression, single-nucleotide-polymorphism genotyping and gene resequencing are becoming more widely adopted. Genomic microarrays are providing an unprecedented opportunity to dissect the genetic risk for complex neurological disorders. Numerous clinical and preclinical applications are likely to dominate the ambitious microarray agenda within the next decade.

Original languageEnglish
Pages (from-to)147-158
Number of pages12
JournalNature Clinical Practice Neurology
Volume2
Issue number3
DOIs
StatePublished - Mar 2006
Externally publishedYes

Keywords

  • Gene resequencing
  • Microarrays
  • Neuro-oncology
  • Neurodegenerative disorders
  • RNA transcript levels

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