TY - GEN
T1 - TDF-TRACT
T2 - 2011 8th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI'11
AU - Gadelkarim, J. J.
AU - Zhan, L.
AU - Yang, S. L.
AU - Zhang, A. F.
AU - Altshuler, L.
AU - Lamar, M.
AU - Ajilore, O.
AU - Thompson, P. M.
AU - Kumar, A.
AU - Leow, A.
PY - 2011
Y1 - 2011
N2 - Fractional anisotropy (FA), a widely used measure of fiber integrity based on diffusion tensor imaging (DTI), is theoretically confounded by several other quantities including the degree of fiber orientation incoherence within each voxel, and partial volume effects from neighboring gray matter or CSF. High angular resolution diffusion imaging (HARDI) can potentially resolve more complex diffusion geometries and thus disentangle confounds from fiber incoherence and partial voluming when assessing fiber integrity. Yet, to date, no study has systematically investigated the clinical implications of this potential advantage. Here, we describe our recent efforts in developing TDF (tensor distribution function) based probabilistic tractography for HARDI. Comparing TDF- and DTI-based tractography results in the genu of corpus callosum, we demonstrated the variable effect of these confounds in images acquired at different spatial resolutions, suggesting possible relevance of adjusting for fiber incoherence when assessing white matter integrity.
AB - Fractional anisotropy (FA), a widely used measure of fiber integrity based on diffusion tensor imaging (DTI), is theoretically confounded by several other quantities including the degree of fiber orientation incoherence within each voxel, and partial volume effects from neighboring gray matter or CSF. High angular resolution diffusion imaging (HARDI) can potentially resolve more complex diffusion geometries and thus disentangle confounds from fiber incoherence and partial voluming when assessing fiber integrity. Yet, to date, no study has systematically investigated the clinical implications of this potential advantage. Here, we describe our recent efforts in developing TDF (tensor distribution function) based probabilistic tractography for HARDI. Comparing TDF- and DTI-based tractography results in the genu of corpus callosum, we demonstrated the variable effect of these confounds in images acquired at different spatial resolutions, suggesting possible relevance of adjusting for fiber incoherence when assessing white matter integrity.
KW - Diffusion tensor imaging
KW - Fractional Anisotropy
KW - High-Angular Resolution Diffusion Imaging
UR - http://www.scopus.com/inward/record.url?scp=80055047724&partnerID=8YFLogxK
U2 - 10.1109/ISBI.2011.5872529
DO - 10.1109/ISBI.2011.5872529
M3 - Conference contribution
AN - SCOPUS:80055047724
SN - 9781424441280
T3 - Proceedings - International Symposium on Biomedical Imaging
SP - 812
EP - 816
BT - 2011 8th IEEE International Symposium on Biomedical Imaging
Y2 - 30 March 2011 through 2 April 2011
ER -