TDCS does not enhance the effects of robot-assisted gait training in patients with subacute stroke

Daniel Leon, Mar Cortes, Jessica Elder, Hatice Kumru, Sara Laxe, Dylan James Edwards, Josep Maria Tormos, Montserrat Bernabeu, Alvaro Pascual-Leone

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


Background: Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique, which can modulate cortical excitability and combined with rehabilitation therapies may improve motor recovery after stroke. Objective: Our aim was to study the feasibility of a 4-week robotic gait training protocol combined with tDCS, and to study tDCS to the leg versus hand motor cortex or sham to improve walking ability in patients after a subacute stroke. Methods: Forty-nine subacute stroke patients underwent 20 daily sessions (5 days a week for 4 weeks) of robotic gait training combined with tDCS. Patients were assigned either to the tDCSleg group (n = 9), receiving 2mA anodal tDCS over the motor cortex leg representation (vertex), or an active control group (n = 17) receiving anodal tDCS over the hand motor cortex area (tDCShand). In addition, we studied 23 matched patients in a control group receiving gait training without tDCS (notDCS). Study outcomes included gait speed (10-meter walking test), and quality of gait, using the Functional Ambulatory Category (FAC) before and after the 4-week training period. Results: Only one patient did not complete the treatment because he presented a minor side-effect. Patients in all three groups showed a significantly improvement in gait speed and FAC. The tDCSleg group did not perform better than the tDCShand or notDCS group. Conclusion: Combined tDCS and robotic training is a safe and feasible procedure in subacute stroke patients. However, adding tDCS to robot-assisted gait training shows no benefit over robotic gait training alone.

Original languageEnglish
Pages (from-to)377-384
Number of pages8
JournalRestorative Neurology and Neuroscience
Issue number4
StatePublished - 2017
Externally publishedYes


  • Robot-assisted gait training
  • subacute stroke
  • transcranial direct current stimulation


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