Tcf3 and Tcf4 are essential for long-term homeostasis of skin epithelia

Hoang Nguyen, Bradley J. Merrill, Lisa Polak, Maria Nikolova, Michael Rendl, Timothy M. Shaver, H. Amalia Pasolli, Elaine Fuchs

Research output: Contribution to journalArticlepeer-review

165 Scopus citations

Abstract

Single-layered embryonic skin either stratifies to form epidermis or responds to Wnt signaling (stabilized Β-catenin) to form hair follicles. Postnatally, stem cells continue to differentially use Wnt signaling in long-term tissue homeostasis. We have discovered that embryonic progenitor cells and postnatal hair follicle stem cells coexpress Tcf3 and Tcf4, which can act as transcriptional activators or repressors. Using loss-of-function studies and transcriptional analyses, we uncovered consequences to the absence of Tcf3 and Tcf4 in skin that only partially overlap with those caused by Β-catenin deficiency. We established roles for Tcf3 and Tcf4 in long-term maintenance and wound repair of both epidermis and hair follicles, suggesting that Tcf proteins have both Wnt-dependent and Wnt-independent roles in lineage determination.

Original languageEnglish
Pages (from-to)1068-1075
Number of pages8
JournalNature Genetics
Volume41
Issue number10
DOIs
StatePublished - Oct 2009

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