@article{245351b4804843129443e96273f7292a,
title = "Tazarotene cream in the treatment of psoriasis: Two multicenter, double-blind, randomized, vehicle-controlled studies of the safety and efficacy of tazarotene creams 0.05% and 0.1% applied once daily for 12 weeks",
abstract = "Background: Tazarotene in a gel formulation is widely used in the treatment of psoriasis. Objective: To determine the efficacy and safety of tazarotene 0.1% and 0.05% creams in the treatment of psoriasis. Methods: A total of 1303 patients participated in 2 clinical trials. Patients applied tazarotene creams 0.1% and 0.05% or vehicle once daily to all psoriatic lesions for 12 weeks followed by a 12-week posttreatment period. Results: Both creams were significantly more effective than vehicle on the basis of an overall assessment of psoriasis, a global response to treatment, and reduction in plaque elevation and scaling. Therapeutic effect was maintained during the posttreatment period. Common adverse events included signs and symptoms of skin irritation. Conclusion: Tazarotene creams were associated with significant reductions in the severity of the clinical signs of psoriasis and were found to be safe with acceptable tolerability. Tazarotene cream 0.1% was generally more effective, although slightly less well tolerated, than the 0.05% cream.",
author = "Weinstein, {Gerald D.} and Koo, {John Y.M.} and Krueger, {Gerald G.} and Lebwohl, {Mark G.} and Lowe, {Nicholas J.} and Menter, {M. Alan} and Lew-Kaya, {Deborah A.} and John Sefton and Gibson, {John R.} and Walker, {Patricia S.} and Ernest Ast and Jerry Bagel and Breneman, {Debra L.} and Bright, {Ross D.} and Davis, {Steven A.} and Madeleine Duvic and Drore Eisen and Feldman, {Steven R.} and Fiedler, {Virginia C.} and Richard Fitzpatrick and Fivenson, {David P.} and Goffe, {Bernard S.} and Hanifin, {Jon M.} and Hong, {Steven R.} and Jones, {Terry M.} and Kempers, {Steven E.} and Kraus, {Stephen J.} and Krusinski, {Paul A.} and Leyden, {James J.} and Maloney, {J. Michael} and Miller, {Bruce H.} and Pariser, {David M.} and Phillips, {Tania J.} and Blas Reyes and Owen Reynolds and Rist, {Toivo E.} and Russo, {Glenn G.} and Shavin, {Joel S.} and Daniel Stewart and Swinyer, {Leonard J.} and Tschen, {Eduardo H.} and Wolf, {David I.}",
year = "2003",
month = may,
day = "1",
doi = "10.1067/mjd.2003.103",
language = "English",
volume = "48",
pages = "760--767",
journal = "Journal of the American Academy of Dermatology",
issn = "0190-9622",
publisher = "Mosby Inc.",
number = "5",
}