Tau phosphorylation, tangles, and neurodegeneration: The chicken or the egg?

Daniel H. Geschwind

Research output: Contribution to journalReview articlepeer-review

119 Scopus citations

Abstract

Pathological aggregation of the microtubule-associated protein tau is a common feature of many neurodegenerative diseases. Although tau aggregation is associated with abnormal tau phosphorylation, the role of phosphorylation in the initiation of neurodegeneration has been unclear. Now, several animal models and data from human patients provide converging evidence that aberrant tau phosphorylation can cause a neurodegenerative phenotype similar to that seen in human neurodegenerative diseases.

Original languageEnglish
Pages (from-to)457-460
Number of pages4
JournalNeuron
Volume40
Issue number3
DOIs
StatePublished - 30 Oct 2003
Externally publishedYes

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