TY - JOUR
T1 - Task-independent acute effects of delta-9-tetrahydrocannabinol on human brain function and its relationship with cannabinoid receptor gene expression
T2 - A neuroimaging meta-regression analysis
AU - CBE Consortium
AU - Gunasekera, Brandon
AU - Davies, Cathy
AU - Blest-Hopley, Grace
AU - Veronese, Mattia
AU - Ramsey, Nick F.
AU - Bossong, Matthijs G.
AU - Radua, Joaquim
AU - Bhattacharyya, Sagnik
AU - Pretzsch, Charlotte
AU - McAlonan, Gráinne
AU - Walter, Carmen
AU - Lötsch, Jörn
AU - Freeman, Tom
AU - Curran, Valerie
AU - Battistella, Giovanni
AU - Fornari, Eleonora
AU - Filho, Geraldo Busatto
AU - Crippa, José Alexandre
AU - Duran, Fabio
AU - Zuardi, Antonio Waldo
N1 - Publisher Copyright:
© 2022 The Authors
PY - 2022/9
Y1 - 2022/9
N2 - The neurobiological mechanisms underlying the effects of delta-9-tetrahydrocannabinol (THC) remain unclear. Here, we examined the spatial acute effect of THC on human regional brain activation or blood flow (hereafter called ‘activation signal’) in a ‘core’ network of brain regions from 372 participants, tested using a within-subject repeated measures design under experimental conditions. We also investigated whether the neuromodulatory effects of THC are related to the local expression of the cannabinoid-type-1 (CB1R) and type-2 (CB2R) receptors. Finally, we investigated the dose-response relationship between THC and key brain substrates. These meta-analytic findings shed new light on the localisation of the effects of THC in the human brain, suggesting that THC has neuromodulatory effects in regions central to many cognitive tasks and processes, related to dose, with greater effects in regions with higher levels of CB1R expression.
AB - The neurobiological mechanisms underlying the effects of delta-9-tetrahydrocannabinol (THC) remain unclear. Here, we examined the spatial acute effect of THC on human regional brain activation or blood flow (hereafter called ‘activation signal’) in a ‘core’ network of brain regions from 372 participants, tested using a within-subject repeated measures design under experimental conditions. We also investigated whether the neuromodulatory effects of THC are related to the local expression of the cannabinoid-type-1 (CB1R) and type-2 (CB2R) receptors. Finally, we investigated the dose-response relationship between THC and key brain substrates. These meta-analytic findings shed new light on the localisation of the effects of THC in the human brain, suggesting that THC has neuromodulatory effects in regions central to many cognitive tasks and processes, related to dose, with greater effects in regions with higher levels of CB1R expression.
KW - Attention
KW - Cannabis
KW - FMRI
KW - Memory
KW - Meta-analysis
KW - Neuroimaging
KW - PET
KW - Reward
KW - Systematic
KW - THC
KW - Tetrahydrocannabinol
UR - http://www.scopus.com/inward/record.url?scp=85135325782&partnerID=8YFLogxK
U2 - 10.1016/j.neubiorev.2022.104801
DO - 10.1016/j.neubiorev.2022.104801
M3 - Review article
C2 - 35914625
AN - SCOPUS:85135325782
SN - 0149-7634
VL - 140
JO - Neuroscience and Biobehavioral Reviews
JF - Neuroscience and Biobehavioral Reviews
M1 - 104801
ER -