Targeting the IL-36 receptor with spesolimab mitigates residual inflammation and prevents generalized pustular psoriasis flares

James G. Krueger; Mrinal K. Sarkar; Mark G. Lebwohl; Akimichi Morita; Kenneth Gordon; Rachael Bogle; Christopher Cole; Anthony Coon; Richard G. Langley; Richard B. Warren; Arash Mostaghimi; Bruce Strober; A. David Burden; Min Zheng; Aaron R. Mangold; Milan J. Anadkat; Jonathan N. Barker; Joseph F. Merola; Lam C. Tsoi; Ming Tang; Kolja Becker; Denis Delic; Christian Thoma; Johann E. Gudjonsson

doi:10.1172/JCI188530

Targeting the IL-36 receptor with spesolimab mitigates residual inflammation and prevents generalized pustular psoriasis flares

James G. Krueger
, Mrinal K. Sarkar
, Mark G. Lebwohl
, Akimichi Morita
, Kenneth Gordon
, Rachael Bogle
, Christopher Cole
, Anthony Coon
, Richard G. Langley
, Richard B. Warren
, Arash Mostaghimi
, Bruce Strober
, A. David Burden
, Min Zheng
, Aaron R. Mangold
, Milan J. Anadkat
, Jonathan N. Barker
, Joseph F. Merola
, Lam C. Tsoi
, Ming Tang

Kolja Becker, Denis Delic, Christian Thoma, Johann E. Gudjonsson

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Original language	English
Article number	e188530
Journal	Journal of Clinical Investigation
Volume	135
Issue number	17
DOIs	https://doi.org/10.1172/JCI188530
State	Published - 2025

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10.1172/JCI188530

Cite this

Krueger, J. G., Sarkar, M. K., Lebwohl, M. G., Morita, A., Gordon, K., Bogle, R., Cole, C., Coon, A., Langley, R. G., Warren, R. B., Mostaghimi, A., Strober, B., David Burden, A., Zheng, M., Mangold, A. R., Anadkat, M. J., Barker, J. N., Merola, J. F., Tsoi, L. C., ... Gudjonsson, J. E. (2025). Targeting the IL-36 receptor with spesolimab mitigates residual inflammation and prevents generalized pustular psoriasis flares. Journal of Clinical Investigation, 135(17), Article e188530. https://doi.org/10.1172/JCI188530

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title = "Targeting the IL-36 receptor with spesolimab mitigates residual inflammation and prevents generalized pustular psoriasis flares",

author = "Krueger, \{James G.\} and Sarkar, \{Mrinal K.\} and Lebwohl, \{Mark G.\} and Akimichi Morita and Kenneth Gordon and Rachael Bogle and Christopher Cole and Anthony Coon and Langley, \{Richard G.\} and Warren, \{Richard B.\} and Arash Mostaghimi and Bruce Strober and \{David Burden\}, A. and Min Zheng and Mangold, \{Aaron R.\} and Anadkat, \{Milan J.\} and Barker, \{Jonathan N.\} and Merola, \{Joseph F.\} and Tsoi, \{Lam C.\} and Ming Tang and Kolja Becker and Denis Delic and Christian Thoma and Gudjonsson, \{Johann E.\}",

year = "2025",

doi = "10.1172/JCI188530",

language = "English",

volume = "135",

journal = "Journal of Clinical Investigation",

issn = "0021-9738",

publisher = "American Society for Clinical Investigation",

number = "17",

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Krueger, JG, Sarkar, MK, Lebwohl, MG, Morita, A, Gordon, K, Bogle, R, Cole, C, Coon, A, Langley, RG, Warren, RB, Mostaghimi, A, Strober, B, David Burden, A, Zheng, M, Mangold, AR, Anadkat, MJ, Barker, JN, Merola, JF, Tsoi, LC, Tang, M, Becker, K, Delic, D, Thoma, C & Gudjonsson, JE 2025, 'Targeting the IL-36 receptor with spesolimab mitigates residual inflammation and prevents generalized pustular psoriasis flares', Journal of Clinical Investigation, vol. 135, no. 17, e188530. https://doi.org/10.1172/JCI188530

TY - JOUR

T1 - Targeting the IL-36 receptor with spesolimab mitigates residual inflammation and prevents generalized pustular psoriasis flares

AU - Krueger, James G.

AU - Sarkar, Mrinal K.

AU - Lebwohl, Mark G.

AU - Morita, Akimichi

AU - Gordon, Kenneth

AU - Bogle, Rachael

AU - Cole, Christopher

AU - Coon, Anthony

AU - Langley, Richard G.

AU - Warren, Richard B.

AU - Mostaghimi, Arash

AU - Strober, Bruce

AU - David Burden, A.

AU - Zheng, Min

AU - Mangold, Aaron R.

AU - Anadkat, Milan J.

AU - Barker, Jonathan N.

AU - Merola, Joseph F.

AU - Tsoi, Lam C.

AU - Tang, Ming

AU - Becker, Kolja

AU - Delic, Denis

AU - Thoma, Christian

AU - Gudjonsson, Johann E.

PY - 2025

Y1 - 2025

UR - https://www.scopus.com/pages/publications/105015178992

U2 - 10.1172/JCI188530

DO - 10.1172/JCI188530

M3 - Article

C2 - 40591420

AN - SCOPUS:105015178992

SN - 0021-9738

VL - 135

JO - Journal of Clinical Investigation

JF - Journal of Clinical Investigation

IS - 17

M1 - e188530

ER -