Targeting Solute Carrier Transporters through Functional Mapping

Claire Colas, Elodie Laine

Research output: Contribution to journalShort surveypeer-review

12 Scopus citations

Abstract

Solute carrier (SLC) transporters are emerging drug targets. Identifying the molecular determinants responsible for their specific and selective transport activities and describing key interactions with their ligands are crucial steps towards the design of potential new drugs. A general functional mapping across more than 400 human SLC transporters would pave the way to the rational and systematic design of molecules modulating cellular transport.

Original languageEnglish
Pages (from-to)3-6
Number of pages4
JournalTrends in Pharmacological Sciences
Volume42
Issue number1
DOIs
StatePublished - Jan 2021
Externally publishedYes

Keywords

  • functional mapping
  • protein evolution
  • protein structure
  • solute carriers

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