TY - JOUR
T1 - Targeting SLC transporters
T2 - small molecules as modulators and therapeutic opportunities
AU - Schlessinger, Avner
AU - Zatorski, Nicole
AU - Hutchinson, Keino
AU - Colas, Claire
N1 - Publisher Copyright:
© 2023 Elsevier Ltd
PY - 2023/9
Y1 - 2023/9
N2 - Solute carrier (SLCs) transporters mediate the transport of a broad range of solutes across biological membranes. Dysregulation of SLCs has been associated with various pathologies, including metabolic and neurological disorders, as well as cancer and rare diseases. SLCs are therefore emerging as key targets for therapeutic intervention with several recently approved drugs targeting these proteins. Unlocking this large and complex group of proteins is essential to identifying unknown SLC targets and developing next-generation SLC therapeutics. Recent progress in experimental and computational techniques has significantly advanced SLC research, including drug discovery. Here, we review emerging topics in therapeutic discovery of SLCs, focusing on state-of-the-art approaches in structural, chemical, and computational biology, and discuss current challenges in transporter drug discovery.
AB - Solute carrier (SLCs) transporters mediate the transport of a broad range of solutes across biological membranes. Dysregulation of SLCs has been associated with various pathologies, including metabolic and neurological disorders, as well as cancer and rare diseases. SLCs are therefore emerging as key targets for therapeutic intervention with several recently approved drugs targeting these proteins. Unlocking this large and complex group of proteins is essential to identifying unknown SLC targets and developing next-generation SLC therapeutics. Recent progress in experimental and computational techniques has significantly advanced SLC research, including drug discovery. Here, we review emerging topics in therapeutic discovery of SLCs, focusing on state-of-the-art approaches in structural, chemical, and computational biology, and discuss current challenges in transporter drug discovery.
KW - drug design
KW - ligand discovery
KW - membrane protein
KW - protein structure prediction
UR - http://www.scopus.com/inward/record.url?scp=85162885782&partnerID=8YFLogxK
U2 - 10.1016/j.tibs.2023.05.011
DO - 10.1016/j.tibs.2023.05.011
M3 - Review article
C2 - 37355450
AN - SCOPUS:85162885782
SN - 0968-0004
VL - 48
SP - 801
EP - 814
JO - Trends in Biochemical Sciences
JF - Trends in Biochemical Sciences
IS - 9
ER -