TY - JOUR
T1 - Targeting of matrix metalloproteinase activation for noninvasive detection of vulnerable atherosclerotic lesions
AU - Hartung, Dagmar
AU - Schäfers, Michael
AU - Fujimoto, Shinichiro
AU - Levkau, Bodo
AU - Narula, Navneet
AU - Kopka, Klaus
AU - Virmani, Renu
AU - Reutelingsperger, Chris
AU - Hofstra, Leo
AU - Kolodgie, Frank D.
AU - Petrov, Artiom
AU - Narula, Jagat
N1 - Funding Information:
Acknowledgments This study was supported by National Institute of Health grant HL-78681 (to Dr. Narula) and Bristol-Myers Squibb grant (to Dr. Narula) as well as by GE Healthcare, Amersham, UK (to Dr. Schäfers and Dr. Levkau) and the German Research Foundation DFG, SFB 656, projects A1 & A2 (to Dr. Schäfers).
PY - 2007/6
Y1 - 2007/6
N2 - Introduction: Inflammation plays an important role in vulnerability of atherosclerotic plaques to rupture and hence acute coronary events. The monocyte-macrophage infiltration in plaques leads to upregulation of cytokines and metalloproteinase enzymes. Matrix metalloproteinases result in matrix dissolution and consequently expansive remodeling of the vessel. They also contribute to attenuation of fibrous cap and hence susceptibility to rupture. Assessment of metalloproteinase expression and activity should provide information about plaque instability.
AB - Introduction: Inflammation plays an important role in vulnerability of atherosclerotic plaques to rupture and hence acute coronary events. The monocyte-macrophage infiltration in plaques leads to upregulation of cytokines and metalloproteinase enzymes. Matrix metalloproteinases result in matrix dissolution and consequently expansive remodeling of the vessel. They also contribute to attenuation of fibrous cap and hence susceptibility to rupture. Assessment of metalloproteinase expression and activity should provide information about plaque instability.
KW - Atherosclerosis
KW - Matrix metalloproteinase
KW - Radionuclide imaging
KW - Thin cap fibroatheroma
KW - Vascular remodeling
UR - https://www.scopus.com/pages/publications/34250784515
U2 - 10.1007/s00259-007-0435-0
DO - 10.1007/s00259-007-0435-0
M3 - Review article
C2 - 17497106
AN - SCOPUS:34250784515
SN - 1619-7070
VL - 34
SP - S1-S8
JO - European Journal of Nuclear Medicine and Molecular Imaging
JF - European Journal of Nuclear Medicine and Molecular Imaging
IS - 1 SUPPL.
ER -