Targeting of matrix metalloproteinase activation for noninvasive detection of vulnerable atherosclerotic lesions

Dagmar Hartung; Michael Schäfers; Shinichiro Fujimoto; Bodo Levkau; Navneet Narula; Klaus Kopka; Renu Virmani; Chris Reutelingsperger; Leo Hofstra; Frank D. Kolodgie; Artiom Petrov; Jagat Narula

doi:10.1007/s00259-007-0435-0

Targeting of matrix metalloproteinase activation for noninvasive detection of vulnerable atherosclerotic lesions

Dagmar Hartung, Michael Schäfers, Shinichiro Fujimoto, Bodo Levkau, Navneet Narula, Klaus Kopka, Renu Virmani, Chris Reutelingsperger, Leo Hofstra, Frank D. Kolodgie, Artiom Petrov, Jagat Narula

Research output: Contribution to journal › Review article › peer-review

29 Scopus citations

Abstract

Introduction: Inflammation plays an important role in vulnerability of atherosclerotic plaques to rupture and hence acute coronary events. The monocyte-macrophage infiltration in plaques leads to upregulation of cytokines and metalloproteinase enzymes. Matrix metalloproteinases result in matrix dissolution and consequently expansive remodeling of the vessel. They also contribute to attenuation of fibrous cap and hence susceptibility to rupture. Assessment of metalloproteinase expression and activity should provide information about plaque instability.

Original language	English
Pages (from-to)	S1-S8
Journal	European Journal of Nuclear Medicine and Molecular Imaging
Volume	34
Issue number	1 SUPPL.
DOIs	https://doi.org/10.1007/s00259-007-0435-0
State	Published - Jun 2007
Externally published	Yes

Keywords

Atherosclerosis
Matrix metalloproteinase
Radionuclide imaging
Thin cap fibroatheroma
Vascular remodeling

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10.1007/s00259-007-0435-0

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Hartung, D., Schäfers, M., Fujimoto, S., Levkau, B., Narula, N., Kopka, K., Virmani, R., Reutelingsperger, C., Hofstra, L., Kolodgie, F. D., Petrov, A., & Narula, J. (2007). Targeting of matrix metalloproteinase activation for noninvasive detection of vulnerable atherosclerotic lesions. European Journal of Nuclear Medicine and Molecular Imaging, 34(1 SUPPL.), S1-S8. https://doi.org/10.1007/s00259-007-0435-0

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title = "Targeting of matrix metalloproteinase activation for noninvasive detection of vulnerable atherosclerotic lesions",

abstract = "Introduction: Inflammation plays an important role in vulnerability of atherosclerotic plaques to rupture and hence acute coronary events. The monocyte-macrophage infiltration in plaques leads to upregulation of cytokines and metalloproteinase enzymes. Matrix metalloproteinases result in matrix dissolution and consequently expansive remodeling of the vessel. They also contribute to attenuation of fibrous cap and hence susceptibility to rupture. Assessment of metalloproteinase expression and activity should provide information about plaque instability.",

keywords = "Atherosclerosis, Matrix metalloproteinase, Radionuclide imaging, Thin cap fibroatheroma, Vascular remodeling",

author = "Dagmar Hartung and Michael Sch{\"a}fers and Shinichiro Fujimoto and Bodo Levkau and Navneet Narula and Klaus Kopka and Renu Virmani and Chris Reutelingsperger and Leo Hofstra and Kolodgie, {Frank D.} and Artiom Petrov and Jagat Narula",

note = "Funding Information: Acknowledgments This study was supported by National Institute of Health grant HL-78681 (to Dr. Narula) and Bristol-Myers Squibb grant (to Dr. Narula) as well as by GE Healthcare, Amersham, UK (to Dr. Sch{\"a}fers and Dr. Levkau) and the German Research Foundation DFG, SFB 656, projects A1 & A2 (to Dr. Sch{\"a}fers).",

year = "2007",

month = jun,

doi = "10.1007/s00259-007-0435-0",

language = "English",

volume = "34",

pages = "S1--S8",

journal = "European Journal of Nuclear Medicine and Molecular Imaging",

issn = "1619-7070",

publisher = "Springer Verlag",

number = "1 SUPPL.",

}

Hartung, D, Schäfers, M, Fujimoto, S, Levkau, B, Narula, N, Kopka, K, Virmani, R, Reutelingsperger, C, Hofstra, L, Kolodgie, FD, Petrov, A & Narula, J 2007, 'Targeting of matrix metalloproteinase activation for noninvasive detection of vulnerable atherosclerotic lesions', European Journal of Nuclear Medicine and Molecular Imaging, vol. 34, no. 1 SUPPL., pp. S1-S8. https://doi.org/10.1007/s00259-007-0435-0

TY - JOUR

T1 - Targeting of matrix metalloproteinase activation for noninvasive detection of vulnerable atherosclerotic lesions

AU - Hartung, Dagmar

AU - Schäfers, Michael

AU - Fujimoto, Shinichiro

AU - Levkau, Bodo

AU - Narula, Navneet

AU - Kopka, Klaus

AU - Virmani, Renu

AU - Reutelingsperger, Chris

AU - Hofstra, Leo

AU - Kolodgie, Frank D.

AU - Petrov, Artiom

AU - Narula, Jagat

N1 - Funding Information: Acknowledgments This study was supported by National Institute of Health grant HL-78681 (to Dr. Narula) and Bristol-Myers Squibb grant (to Dr. Narula) as well as by GE Healthcare, Amersham, UK (to Dr. Schäfers and Dr. Levkau) and the German Research Foundation DFG, SFB 656, projects A1 & A2 (to Dr. Schäfers).

PY - 2007/6

Y1 - 2007/6

N2 - Introduction: Inflammation plays an important role in vulnerability of atherosclerotic plaques to rupture and hence acute coronary events. The monocyte-macrophage infiltration in plaques leads to upregulation of cytokines and metalloproteinase enzymes. Matrix metalloproteinases result in matrix dissolution and consequently expansive remodeling of the vessel. They also contribute to attenuation of fibrous cap and hence susceptibility to rupture. Assessment of metalloproteinase expression and activity should provide information about plaque instability.

AB - Introduction: Inflammation plays an important role in vulnerability of atherosclerotic plaques to rupture and hence acute coronary events. The monocyte-macrophage infiltration in plaques leads to upregulation of cytokines and metalloproteinase enzymes. Matrix metalloproteinases result in matrix dissolution and consequently expansive remodeling of the vessel. They also contribute to attenuation of fibrous cap and hence susceptibility to rupture. Assessment of metalloproteinase expression and activity should provide information about plaque instability.

KW - Atherosclerosis

KW - Matrix metalloproteinase

KW - Radionuclide imaging

KW - Thin cap fibroatheroma

KW - Vascular remodeling

UR - http://www.scopus.com/inward/record.url?scp=34250784515&partnerID=8YFLogxK

U2 - 10.1007/s00259-007-0435-0

DO - 10.1007/s00259-007-0435-0

M3 - Review article

C2 - 17497106

AN - SCOPUS:34250784515

SN - 1619-7070

VL - 34

SP - S1-S8

JO - European Journal of Nuclear Medicine and Molecular Imaging

JF - European Journal of Nuclear Medicine and Molecular Imaging

IS - 1 SUPPL.

ER -

Targeting of matrix metalloproteinase activation for noninvasive detection of vulnerable atherosclerotic lesions

Abstract

Keywords

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