Targeting ischemic penumbra part II: Selective drug delivery using liposome technologies

Shimin Liu, Steven R. Levine, Richard Winn

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations

Abstract

In the present review (part II), we discuss the challenges and promises of selective drug delivery to ischemic brain tissue by liposome technologies. In part I of this serial review, we proposed "selective drug delivery to ischemic brain tissue" as a technique for neuroprotective treatment of acute ischemic stroke. To be effective, drugs must pass a series of barriers to arrive at ischemic brain. Brain ischemia results in metabolic and structur-al changes in the ischemic region, which cause additional obstacles for drug delivery. Liposome drug delivery system can pass these barriers and selectively target ischemic tissue by utilizing ischemia-induced changes in metabolism and molecular structure.

Original languageEnglish
Pages (from-to)16-23
Number of pages8
JournalJournal of Experimental Stroke and Translational Medicine
Volume4
Issue number1
DOIs
StatePublished - 2011
Externally publishedYes

Keywords

  • Blood-brain barrier
  • Drug delivery
  • Liposome
  • PH-sensitive
  • Penumbra

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