Abstract
In the present review (part II), we discuss the challenges and promises of selective drug delivery to ischemic brain tissue by liposome technologies. In part I of this serial review, we proposed "selective drug delivery to ischemic brain tissue" as a technique for neuroprotective treatment of acute ischemic stroke. To be effective, drugs must pass a series of barriers to arrive at ischemic brain. Brain ischemia results in metabolic and structur-al changes in the ischemic region, which cause additional obstacles for drug delivery. Liposome drug delivery system can pass these barriers and selectively target ischemic tissue by utilizing ischemia-induced changes in metabolism and molecular structure.
| Original language | English |
|---|---|
| Pages (from-to) | 16-23 |
| Number of pages | 8 |
| Journal | Journal of Experimental Stroke and Translational Medicine |
| Volume | 4 |
| Issue number | 1 |
| DOIs | |
| State | Published - 2011 |
| Externally published | Yes |
Keywords
- Blood-brain barrier
- Drug delivery
- Liposome
- PH-sensitive
- Penumbra