Targeting ischemic penumbra part I: From pathophysiology to therapeutic strategy

Shimin Liu, Steven R. Levine, Richard Winn

Research output: Contribution to journalReview articlepeer-review

88 Scopus citations

Abstract

Penumbra is the viable tissue around the irreversibly damaged ischemic core. The purpose of acute stroke treatment is to salvage penumbral tissue and to improve brain function. However, the majority of acute stroke patients who have treatable penumbra are left untreated. Therefore, developing an effective nonrecanalizational therapeutics, such as neuroprotective agents, has significant clinical applications. Part I of this serial review on "targeting penumbra" puts special emphases on penumbral pathophysiology and the development of therapeutic strategies. Bioenergetic intervention by massive metabolic suppression and direct energy delivery would be a promising future direction. An effective drug delivery system for this purpose should be able to penetrate BBB and achieve high local tissue drug levels while non-ischemic region being largely unaffected. Selective drug delivery to ischemic stroke penumbra is feasible and deserves intensive research.

Original languageEnglish
Pages (from-to)47-55
Number of pages9
JournalJournal of Experimental Stroke and Translational Medicine
Volume3
Issue number1
DOIs
StatePublished - 2010
Externally publishedYes

Keywords

  • Cerebral energy metabolism
  • Cerebral ischemia
  • Energy state
  • Neuroprotection
  • Penumbra
  • Stroke
  • Treatment

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